Periodontitis is a complex disease:(a) various causative factors play a role simultaneously
and interact with each other; and (b) the disease is episodic in nature, and bursts of disease …

Many systems on our planet shift abruptly and irreversibly from the desired state to an
undesired state when forced across a “tipping point”. Some examples are mass extinctions …

All life requires the capacity to recover from challenges that are as inevitable as they are
unpredictable. Understanding this resilience is essential for managing the health of humans …

Cell fate choice and commitment of multipotent progenitor cells to a differentiated lineage
requires broad changes of their gene expression profile. But how progenitor cells overcome …

Chronic diseases (ie, noncommunicable diseases), mainly cardiovascular disease, cancer,
respiratory diseases and type-2-diabetes, are now the leading cause of death, disability and …

We develop and test machine learning techniques for successfully using past state time
series data and knowledge of a time-dependent system parameter to predict the evolution of …

In an ecosystem, environmental changes as a result of natural and human processes can
cause some key parameters of the system to change with time. Depending on how fast such …

Objective: We propose a novel paradigm to predict acute attacks and exacerbations in
chronic episodic disorders such as asthma, cardiac arrhythmias, migraine, epilepsy, and …

The possibility to anticipate critical transitions through detecting loss of resilience has
attracted attention in many fields. Resilience indicators rely on the mathematical concept of …

Background: We currently still lack valid methods to dynamically measure resilience for
stressors before the appearance of adverse health outcomes that hamper well-being …