The endotoxin hypothesis of neurodegeneration is the hypothesis that endotoxin causes or
contributes to neurodegeneration. Endotoxin is a lipopolysaccharide (LPS), constituting …

Sepsis is a potentially fatal condition caused by dysregulation of the body's immune
response to an infection. Sepsis-induced liver injury is considered a strong independent …

Infection and inflammation induce the acutephase response (APR), leading to multiple
alterations in lipid and lipoprotein metabolism. Plasma triglyceride levels increase from …

Bacterial sepsis and septic shock result from the overproduction of inflammatory mediators
as a consequence of the interaction of the immune system with bacteria and bacterial wall …

Endotoxin, also referred to as lipopolysaccharide (LPS), can stimulate localized or systemic
inflammation via the activation of pattern recognition receptors. Additionally, endotoxin and …

Human longevity is a complex phenotype resulting from the combinations of context-
dependent gene-environment interactions that require analysis as a dynamic process in a …

Objective—Apolipoprotein E (apoE) exerts potent antiinflammatory effects. Here, we
investigated the effect of apoE on the functional phenotype of macrophages. Methods and …

Abstract Apolipoprotein E (apoE), a 34 kDa glycoprotein, mediates hepatic and extrahepatic
uptake of plasma lipoproteins and cholesterol efflux from lipid-laden macrophages. In …

Human apolipoprotein E is the major apolipoprotein expressed in the brain and exists as
three isoforms, designated E2, E3, and E4. Although evidence suggests that apolipoprotein …

Physiologically, lipopolysaccharide (LPS) is present in the bloodstream and can be bound to
several proteins for its transport (ie) LPS binding protein (LBP) and plasma lipoproteins) …