An overview of recent advances in biomedical applications of click chemistry

J Kaur, M Saxena, N Rishi - Bioconjugate chemistry, 2021 - ACS Publications
Cu (I)-catalyzed azide–alkyne cycloaddition (CuAAC) is a modular and bio-orthogonal
approach that is being adopted for the efficient synthesis of organic and bioorganic …

Mono-and sesquiterpenes as a starting platform for the development of antiviral drugs

OI Yarovaya, NF Salakhutdinov - Russian Chemical Reviews, 2021 - iopscience.iop.org
The revies focuses on low-molecular-weight plant metabolites (mono-and sesquiterpenes)
exhibiting antiviral activity. Data on antiviral action of both essential oils and plant extracts …

Quinoline hydrazide/hydrazone derivatives: Recent insights on antibacterial activity and mechanism of action

S Verma, S Lal, R Narang, K Sudhakar - ChemMedChem, 2023 - Wiley Online Library
Antibiotics are becoming gradually ineffective due to drug resistance, leading to greater
difficulty in the treatment of infectious diseases. Therefore, the development of new chemical …

Synthesis, antimalarial and antioxidant activity of coumarin appended 1, 4-disubstituted 1, 2, 3-triazoles

CP Kaushik, M Chahal - Monatshefte für Chemie-Chemical Monthly, 2021 - Springer
A series of coumarin appended triazole hybrids of biotic interest was synthesized through
click chemistry approach from the coumarin based terminal alkynes and aromatic azides. All …

Synthesis and in vitro study of artemisinin/synthetic peroxide‐based hybrid compounds against SARS‐CoV‐2 and cancer

L Herrmann, IA Yaremenko, A Çapcı, J Struwe… - …, 2022 - Wiley Online Library
The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) cause
life‐threatening diseases in millions of people worldwide, in particular, in patients with …

[HTML][HTML] Molecular insights into artemisinin resistance in Plasmodium falciparum: An updated review

WA Azmi, AFM Rizki, Y Djuardi, IM Artika… - Infection, Genetics and …, 2023 - Elsevier
Malaria still poses a major burden on human health around the world, especially in endemic
areas. Plasmodium resistance to several antimalarial drugs has been one of the major …

Autofluorescent Artemisinin‐Benzimidazole Hybrids via Organo‐Click Reaction: Study of Antiviral Properties and Mode of Action in Living Cells

L Herrmann, F Hahn, BW Grau, M Wild… - … A European Journal, 2023 - Wiley Online Library
Drug modification by a fluorescent label is a common tool for studying its mechanism of
action with fluorescence microscopy techniques. However, the attachment of a fluorescent …

Combinatorial drug treatments reveal promising anticytomegaloviral profiles for clinically relevant pharmaceutical kinase inhibitors (PKIs)

M Wild, J Kicuntod, L Seyler, C Wangen… - International journal of …, 2021 - mdpi.com
Human cytomegalovirus (HCMV) is a human pathogenic herpesvirus associated with a
variety of clinical symptoms. Current antiviral therapy is not always effective, so that …

Cyclodextrin-based multifunctional supramolecular catalysts for aqueous CuAAC reaction

J Li, X Feng, W Wang, M Guo, J Yang, X Li… - Applied Catalysis A …, 2023 - Elsevier
As an excellent bioorthogonal reaction, CuAAC reaction has been widely used in biological
research. In this work, three cyclodextrin derivatives β-CD-3, β-CD-4 and CD-P were …

Nanometals: As click catalysts for 1, 4-triazole cycloaddition (2020-till date)

KT Jha, PA Chawla - Sustainable Chemistry and Pharmacy, 2023 - Elsevier
In recent years, the search for efficient and sustainable catalysts for click chemistry has
gained significant attention. The process of copper-catalyzed azide-alkyne cycloaddition …