ATF4 is a cellular stress induced bZIP transcription factor that is a hallmark effector of the
integrated stress response. The integrated stress response is triggered by phosphorylation …

The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …

The IntAct molecular interaction database (https://www. ebi. ac. uk/intact) is a curated
resource of molecular interactions, derived from the scientific literature and from direct data …

Network medicine has proven useful for dissecting genetic organization of complex human
diseases. We have previously published HumanNet, an integrated network of human genes …

Facial morphology—a conspicuous feature of human appearance—is highly heritable.
Previous studies on the genetic basis of facial morphology were performed mainly in …

Lysosomes are well-established as the main cellular organelles for the degradation of
macromolecules and emerging as regulatory centers of metabolism. They are of crucial …

Multitarget anti-Alzheimer agents are the focus of very intensive research. Through a
comprehensive bibliometric analysis of the publications in the period 1990–2020, we have …

Protein-protein interactions (PPIs) are a key component of the subcellular molecular
networks which enable cells to function. Due to their importance in homeostasis, alterations …

Blood brain barrier (BBB) breakdown is a key driver of traumatic brain injury (TBI),
contributing to prolonged neurological deficits and increased risk of death in TBI patients …

The ATPase p97 (also known as VCP, Cdc48) has crucial functions in a variety of important
cellular processes such as protein quality control, organellar homeostasis, and DNA …