Protein export through the bacterial Sec pathway
A Tsirigotaki, J De Geyter, A Economou… - Nature Reviews …, 2017 - nature.com
The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …
export machinery for most proteins that integrate into, or translocate through, the plasma …
Structural and mechanistic insights into protein translocation
Many proteins are translocated across the endoplasmic reticulum (ER) membrane in
eukaryotes or the plasma membrane in prokaryotes. These proteins use hydrophobic signal …
eukaryotes or the plasma membrane in prokaryotes. These proteins use hydrophobic signal …
Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum
Protein synthesis, transport, and N-glycosylation are coupled at the mammalian
endoplasmic reticulum by complex formation of a ribosome, the Sec61 protein-conducting …
endoplasmic reticulum by complex formation of a ribosome, the Sec61 protein-conducting …
[HTML][HTML] Structure of the mammalian ribosome-Sec61 complex to 3.4 Å resolution
Cotranslational protein translocation is a universally conserved process for secretory and
membrane protein biosynthesis. Nascent polypeptides emerging from a translating …
membrane protein biosynthesis. Nascent polypeptides emerging from a translating …
Mechanisms of Sec61/SecY-mediated protein translocation across membranes
E Park, TA Rapoport - Annual review of biophysics, 2012 - annualreviews.org
The Sec61 or SecY channel, a universally conserved protein-conducting channel,
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …
Arrest Peptides: Cis-Acting Modulators of Translation
K Ito, S Chiba - Annual review of biochemistry, 2013 - annualreviews.org
Each peptide bond of a protein is generated at the peptidyl transferase center (PTC) of the
ribosome and then moves through the exit tunnel, which accommodates ever-changing …
ribosome and then moves through the exit tunnel, which accommodates ever-changing …
Crystal structure of a substrate-engaged SecY protein-translocation channel
Hydrophobic signal sequences target secretory polypeptides to a protein-conducting
channel formed by a heterotrimeric membrane protein complex, the prokaryotic SecY or …
channel formed by a heterotrimeric membrane protein complex, the prokaryotic SecY or …
Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion
M Gogala, T Becker, B Beatrix, JP Armache… - Nature, 2014 - nature.com
The biogenesis of secretory as well as transmembrane proteins requires the activity of the
universally conserved protein-conducting channel (PCC), the Sec61 complex (SecY …
universally conserved protein-conducting channel (PCC), the Sec61 complex (SecY …
[HTML][HTML] Protein translocation across the inner membrane of Gram-negative bacteria: the Sec and Tat dependent protein transport pathways
R Kudva, K Denks, P Kuhn, A Vogt, M Müller… - Research in …, 2013 - Elsevier
Gram negative bacteria possess a large variety of protein transport systems, by which
proteins that are synthesised in the cytosol are exported to destinations in the cell envelope …
proteins that are synthesised in the cytosol are exported to destinations in the cell envelope …
Highlighting membrane protein structure and function: A celebration of the Protein Data Bank
Biological membranes define the boundaries of cells and compartmentalize the chemical
and physical processes required for life. Many biological processes are carried out by …
and physical processes required for life. Many biological processes are carried out by …