Post-translational modification of proteins by ubiquitin is required for nearly all aspects of
eukaryotic cell function. The numerous targets of ubiquitylation, and variety of ubiquitin …

The Ubiquitin Proteasome System (UPS) is responsible for the degradation of misfolded or
aggregated proteins via a multistep ATP-dependent proteolytic mechanism. This process …

Human papillomavirus (HPV) is a DNA virus that causes sexually transmitted infections. The
HPV oncoprotein E7 plays a critical role in the regulation of host immunity to promote the …

Enzymes are powerful tools for protein labelling due to their specificity and mild reaction
conditions. Many protocols, however, are restricted to modifications at protein termini, rely on …

Hereditary Parkinson's disease is commonly caused by mutations in the protein kinase
PINK1 or the E3 ubiquitin ligase Parkin, which function together to eliminate damaged …

The ubiquitin-proteasome system (UPS) is a regulated mechanism of intracellular protein
degradation and turnover, and its dysfunction is associated with various diseases including …

Background Plants respond to abiotic stress on physiological, biochemical and molecular
levels. This includes a global change in their cellular proteome achieved by changes in the …

Ring-between-ring (RBR) E3 ligases have been implicated in autoimmune disorders and
neurodegenerative diseases. The functions of many RBR E3s are poorly defined, and their …

Gordon Holmes syndrome (GDHS) is an adult-onset neurodegenerative disorder
characterized by ataxia and hypogonadotropic hypogonadism. GDHS is caused by …

Protein post‐translational modification with ubiquitin (Ub) is a versatile signal regulating
almost all aspects of cell biology, and an increasing range of diseases is associated with …