The soil-dwelling social amoeba Dictyostelium discoideum feeds on bacteria. Each meal is
a potential infection because some bacteria have evolved mechanisms to resist predation …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

In recent years, Dictyostelium discoideum has become an important model organism to
study the cell biology of professional phagocytes. This amoeba not only shares many …

Low-glucose and-insulin conditions, associated with ketogenic diets, can reduce the activity
of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway, potentially …

Macropinocytosis is a conserved endocytic process used by Dictyostelium amoebae for
feeding on liquid medium. To further Dictyostelium as a model for macropinocytosis, we …

Mutations in CLN5 cause a subtype of neuronal ceroid lipofuscinosis (NCL) called CLN5
disease. While the precise role of CLN5 in NCL pathogenesis is not known, recent work …

Background Tetrandrine, a bisbenzylisoquinoline alkaloid that was isolated from the
medicinal plant Stephania tetrandrine S. Moore, was recently identified as a novel …

In the current study, the therapeutic potential of cerium oxide nanoparticles (nCeO 2) was
investigated in a human tau (htau) model of Alzheimer's disease (AD), using Drosophila …

WIPIs are a conserved family of proteins with a characteristic 7-bladed β-propeller structure.
They play a prominent role in autophagy, but also in other membrane trafficking processes …

Macroautophagy, a highly conserved and complex intracellular degradative pathway,
involves more than 20 core autophagy (ATG) proteins, among them the hexameric ATG12 …