Neurorestorative therapy for stroke

J Chen, P Venkat, A Zacharek… - Frontiers in human …, 2014 - frontiersin.org
Ischemic stroke is responsible for many deaths and long-term disability world wide.
Development of effective therapy has been the target of intense research. Accumulating …

[HTML][HTML] The role of microRNAs in self-renewal and differentiation of mesenchymal stem cells

L Guo, RCH Zhao, Y Wu - Experimental hematology, 2011 - Elsevier
MicroRNAs (miRNAs) are short non-coding RNAs involved in post-trascriptional regulation
of gene expression and diverse biological activities. They are crucial for self-renewal and …

Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI

D Kim, H Nishida, SY An, AK Shetty… - Proceedings of the …, 2016 - National Acad Sciences
Extracellular vesicles (EVs) secreted by cells present an attractive strategy for developing
new therapies, but progress in the field is limited by several issues: The quality of the EVs …

Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth

H Xin, Y Li, B Buller, M Katakowski, Y Zhang… - Stem …, 2012 - academic.oup.com
Multipotent mesenchymal stromal cells (MSCs) have potential therapeutic benefit for the
treatment of neurological diseases and injury. MSCs interact with and alter brain …

Exosomes derived from bone marrow mesenchymal stem cells promote angiogenesis in ischemic stroke mice via upregulation of MiR-21-5p

H Hu, X Hu, L Li, Y Fang, Y Yang, J Gu, J Xu, L Chu - Biomolecules, 2022 - mdpi.com
Exosomes derived from bone mesenchymal stem cells (BMSC-Exos) are one of the main
factors responsible for the therapeutic effects of BMSCs. The study aimed to investigate …

Mesenchymal stem cells as a multimodal treatment for nervous system diseases

B Badyra, M Sułkowski, O Milczarek… - Stem Cells …, 2020 - academic.oup.com
Neurological disorders are a massive challenge for modern medicine. Apart from the fact
that this group of diseases is the second leading cause of death worldwide, the majority of …

Therapeutic advancement in neuronal transdifferentiation of mesenchymal stromal cells for neurological disorders

P Choudhary, A Gupta, S Singh - Journal of Molecular Neuroscience, 2021 - Springer
Neurodegenerative disorders have become the leading cause of chronic pain and death.
Treatments available are not sufficient to help the patients as they only alleviate the …

Exploring the cell signalling in hepatocyte differentiation

R Vasconcellos, ÉC Alvarenga, RC Parreira, SS Lima… - Cellular signalling, 2016 - Elsevier
The liver is the second largest organ in the human body and is responsible for several
functions that directly contribute to homeostasis. Hepatocytes are the main parenchymal …

MicroRNAs and their potential therapeutic applications in neural tissue engineering

LH Nguyen, HJ Diao, SY Chew - Advanced Drug Delivery Reviews, 2015 - Elsevier
The inherent poor regeneration capacity of nerve tissues, especially in the central nervous
system, poses a grand challenge for neural tissue engineering. After injuries, the local …

MicroRNA expression patterns in human anterior cingulate and motor cortex: A study of dementia with Lewy bodies cases and controls

PT Nelson, WX Wang, SA Janse, KL Thompson - Brain research, 2018 - Elsevier
Overview MicroRNAs (miRNAs) have been implicated in neurodegenerative diseases
including Parkinson's disease and Alzheimer's disease (AD). Here, we evaluated the …