Skeletal muscle fat infiltration (known as myosteatosis) is an ectopic fat depot that increases
with aging and is recognized to negatively correlate with muscle mass, strength, and mobility …

This scientometric review of genome-wide association studies (GWAS) from 2005 to 2018
(3639 studies; 3508 traits) reveals extraordinary increases in sample sizes, rates of …

Nonalcoholic fatty liver disease (NAFLD) is common and partially heritable and has no
effective treatments. We carried out a genome-wide association study (GWAS) meta …

The health effects of omega-3 fatty acids have been controversial. Here we report the results
of a de novo pooled analysis conducted with data from 17 prospective cohort studies …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Objective To determine changes in the incidence of dementia between 1988 and 2015.
Methods This analysis was performed in aggregated data from individuals> 65 years of age …

With the growing number of genetic association studies, the genotype-phenotype atlas has
become increasingly more complex, yet the functional consequences of most disease …

General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Proteins circulating in the blood are critical for age-related disease processes; however, the
serum proteome has remained largely unexplored. To this end, 4137 proteins covering most …

We identified rare coding variants associated with Alzheimer's disease in a three-stage case–
control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole …