Mechanical stimuli have fundamental roles in articular cartilage during health and disease.
Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) …

Background Lameness is a debilitating condition in equine athletes that leads to more
performance limitation and loss of use than any other medical condition. There are a limited …

Patients with knee osteoarthritis often receive glucocorticoid (GC) or hyaluronic acid (HA)
injections to alleviate symptoms. This study evaluated the impact of Triamcinolone …

Objective Lubricin is increasingly being evaluated as an outcome measure in studies
investigating post-traumatic and naturally occurring osteoarthritis. However, there are …

Progressive cartilage degradation, synovial inflammation, and joint lubrication dysfunction
are key markers of osteoarthritis. The composition of synovial fluid (SF) is altered in OA, with …

Articular joints facilitate motion and transfer loads to underlying bone through a combination
of cartilage tissue and synovial fluid, which together generate a low‐friction contact surface …

Inflammation of the synovium, known as synovitis, plays an important role in the
pathogenesis of osteoarthritis (OA). Synovitis involves the release of a wide variety of pro …

Cytophagocytic mononuclear (CPM) cells, previously known as Reiter's cells, are
macrophages containing apoptotic polymorphonuclear leucocytes. Although they can be …

Inferior synovial lubrication is a hallmark of osteoarthritis (OA), and synovial fluid (SF)
lubrication and composition are variable among OA patients. Hyaluronic acid (HA) …

Articular cartilage is one of the most remarkable load bearing materials found in nature. Its
unique composition provides some of the lowest friction coefficients ever measured and …