Sickle cell disease is the most common cause of stroke in childhood, both ischaemic and
haemorrhagic, and it also affects adults with the condition. Without any screening or …

Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

All patients with HbSS (SCA) share the same genetic mutation but the clinical phenotype is
variable and difficult to predict early in life. A reliable severity predictor would be invaluable …

The recently completed BABY HUG trial investigated the safety and efficacy of hydroxyurea
in infants with sickle cell anemia (SCA). To investigate the effects of known genetic …

The study estimated α-thalassemia (α-thal) prevalence and assessed its associations with
clinical and hematological features in a random sample of Brazilian children with sickle cell …

Sickle cell anemia (SCA)-associated cerebral vasculopathy and moyamoya is a unique
entity reflecting the abnormal interactions between sickled red blood cells (RBCs) and the …

Latin Americans are an underappreciated population affected by sickle cell disease (SCD).
Sickle trait and SCD exist throughout Latin America and US Latino communities. We …

Cerebrovascular disease (CVD) is a severe complication associated with sickle cell anemia.
Abnormal transcranial Doppler (TCD) identifies some children at high risk, but other markers …

In sickle cell anemia (SCA), beta S-globin haplotypes represent the ethnic group or
geographic region from which patients originated. The haplotypes include Senegal (SEN) …

Stroke is a severe clinical manifestation of sickle cell anemia (SCA). Despite the prognostic
relevance of transcranial Doppler (TCD), more accurate tools to assess stroke risk in …