Advancing cell therapy for neurodegenerative diseases

S Temple - Cell stem cell, 2023 - cell.com
Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …

Neural cells for neurodegenerative diseases in clinical trials

Y Fan, ELK Goh, JKY Chan - Stem Cells Translational Medicine, 2023 - academic.oup.com
Neurodegenerative diseases (ND) are an entire spectrum of clinical conditions that affect the
central and peripheral nervous system. There is no cure currently, with treatment focusing …

Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq

S Udani, J Langerman, D Koo, S Baghdasarian… - Nature …, 2024 - nature.com
Cells secrete numerous bioactive molecules that are essential for the function of healthy
organisms. However, scalable methods are needed to link individual cell secretions to their …

Challenges in the clinical advancement of cell therapies for Parkinson's disease

S Skidmore, RA Barker - Nature biomedical engineering, 2023 - nature.com
Cell therapies as potential treatments for Parkinson's disease first gained traction in the
1980s, owing to the clinical success of trials that used transplants of foetal midbrain …

Astrocytes as master modulators of neural networks: Synaptic functions and disease‐associated dysfunction of astrocytes

JA Stogsdill, CC Harwell… - Annals of the New York …, 2023 - Wiley Online Library
Astrocytes are the most abundant glial cell type in the central nervous system and are
essential to the development, plasticity, and maintenance of neural circuits. Astrocytes are …

[HTML][HTML] Roadmap for C9ORF72 in frontotemporal dementia and amyotrophic lateral sclerosis: report on the C9ORF72 FTD/ALS summit

R Sattler, BJ Traynor, J Robertson… - Neurology and …, 2023 - Springer
A summit held March 2023 in Scottsdale, Arizona (USA) focused on the intronic
hexanucleotide expansion in the C9ORF72 gene and its relevance in frontotemporal …

[HTML][HTML] Cell therapy in ALS: An update on preclinical and clinical studies

F Sironi, F De Marchi, L Mazzini, C Bendotti - Brain Research Bulletin, 2023 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by the loss of motor neurons and neuromuscular impairment leading to …

[HTML][HTML] Microglia and astrocytes in amyotrophic lateral sclerosis: disease-associated states, pathological roles, and therapeutic potential

J You, MMM Youssef, JR Santos, J Lee, J Park - Biology, 2023 - mdpi.com
Simple Summary Amyotrophic lateral sclerosis (ALS) is a disease characterized by the
death of motor neurons that results in progressive muscle weakness and paralysis …

[HTML][HTML] Astrocytes: dissecting their diverse roles in amyotrophic lateral sclerosis and frontotemporal dementia

CF Valori, C Sulmona, L Brambilla, D Rossi - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal
neurodegenerative disorders often co-occurring in the same patient, a feature that suggests …

[HTML][HTML] Regenerative medicine strategies for chronic complete spinal cord injury

S Hashimoto, N Nagoshi, M Nakamura… - Neural Regeneration …, 2024 - journals.lww.com
Spinal cord injury is a condition in which the parenchyma of the spinal cord is damaged by
trauma or various diseases. While rapid progress has been made in regenerative medicine …