Advancing cell therapy for neurodegenerative diseases
S Temple - Cell stem cell, 2023 - cell.com
Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …
Neural cells for neurodegenerative diseases in clinical trials
Neurodegenerative diseases (ND) are an entire spectrum of clinical conditions that affect the
central and peripheral nervous system. There is no cure currently, with treatment focusing …
central and peripheral nervous system. There is no cure currently, with treatment focusing …
Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq
Cells secrete numerous bioactive molecules that are essential for the function of healthy
organisms. However, scalable methods are needed to link individual cell secretions to their …
organisms. However, scalable methods are needed to link individual cell secretions to their …
Challenges in the clinical advancement of cell therapies for Parkinson's disease
S Skidmore, RA Barker - Nature biomedical engineering, 2023 - nature.com
Cell therapies as potential treatments for Parkinson's disease first gained traction in the
1980s, owing to the clinical success of trials that used transplants of foetal midbrain …
1980s, owing to the clinical success of trials that used transplants of foetal midbrain …
Astrocytes as master modulators of neural networks: Synaptic functions and disease‐associated dysfunction of astrocytes
JA Stogsdill, CC Harwell… - Annals of the New York …, 2023 - Wiley Online Library
Astrocytes are the most abundant glial cell type in the central nervous system and are
essential to the development, plasticity, and maintenance of neural circuits. Astrocytes are …
essential to the development, plasticity, and maintenance of neural circuits. Astrocytes are …
[HTML][HTML] Roadmap for C9ORF72 in frontotemporal dementia and amyotrophic lateral sclerosis: report on the C9ORF72 FTD/ALS summit
A summit held March 2023 in Scottsdale, Arizona (USA) focused on the intronic
hexanucleotide expansion in the C9ORF72 gene and its relevance in frontotemporal …
hexanucleotide expansion in the C9ORF72 gene and its relevance in frontotemporal …
[HTML][HTML] Cell therapy in ALS: An update on preclinical and clinical studies
F Sironi, F De Marchi, L Mazzini, C Bendotti - Brain Research Bulletin, 2023 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by the loss of motor neurons and neuromuscular impairment leading to …
characterized by the loss of motor neurons and neuromuscular impairment leading to …
[HTML][HTML] Microglia and astrocytes in amyotrophic lateral sclerosis: disease-associated states, pathological roles, and therapeutic potential
Simple Summary Amyotrophic lateral sclerosis (ALS) is a disease characterized by the
death of motor neurons that results in progressive muscle weakness and paralysis …
death of motor neurons that results in progressive muscle weakness and paralysis …
[HTML][HTML] Astrocytes: dissecting their diverse roles in amyotrophic lateral sclerosis and frontotemporal dementia
CF Valori, C Sulmona, L Brambilla, D Rossi - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal
neurodegenerative disorders often co-occurring in the same patient, a feature that suggests …
neurodegenerative disorders often co-occurring in the same patient, a feature that suggests …
[HTML][HTML] Regenerative medicine strategies for chronic complete spinal cord injury
S Hashimoto, N Nagoshi, M Nakamura… - Neural Regeneration …, 2024 - journals.lww.com
Spinal cord injury is a condition in which the parenchyma of the spinal cord is damaged by
trauma or various diseases. While rapid progress has been made in regenerative medicine …
trauma or various diseases. While rapid progress has been made in regenerative medicine …