Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated
tumor suppressor genes in human cancers, especially in glioma, and recent findings …

Fifteen per cent of cancers maintain telomere length independently of telomerase by the
homologous recombination (HR)-associated alternative lengthening of telomeres (ALT) …

Mutational inactivation of ATRX (α-thalassemia mental retardation X-linked) represents a
defining molecular alteration in large subsets of malignant glioma. Yet the pathogenic …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

Recent genome sequencing efforts in a variety of cancers have revealed mutations and/or
structural alterations in ATRX and DAXX, which together encode a complex that deposits …

Histone H3. 3 is a highly conserved histone H3 replacement variant in metazoans and has
been implicated in many important biological processes, including cell differentiation and …

ATRX is a tumor suppressor that has been associated with protection from DNA replication
stress, purportedly through resolution of difficult-to-replicate G-quadruplex (G4) DNA …

Introduction: ATRX is a chromatin remodeling protein whose main function is the deposition
of the histone variant H3. 3. ATRX mutations are widely distributed in glioma, and correlate …

The excessive production of reactive oxygen species (ROS) can lead to single nucleic acid
base damage, DNA strand breakage, inter-and intra-strand cross-linking of nucleic acids …