High‐throughput metabolomics by 1D NMR

A Vignoli, V Ghini, G Meoni, C Licari… - Angewandte Chemie …, 2019 - Wiley Online Library
Metabolomics deals with the whole ensemble of metabolites (the metabolome). As one of
the‐omic sciences, it relates to biology, physiology, pathology and medicine; but metabolites …

Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

DJ Hausenloy, D Garcia-Dorado… - Cardiovascular …, 2017 - academic.oup.com
Ischaemic heart disease and the heart failure that often results, remain the leading causes of
death and disability in Europe and worldwide. As such, in order to prevent heart failure and …

[HTML][HTML] SARS-CoV-2 infection dysregulates the metabolomic and lipidomic profiles of serum

C Bruzzone, M Bizkarguenaga, R Gil-Redondo… - Iscience, 2020 - cell.com
COVID-19 is a systemic infection that exerts significant impact on the metabolism. Yet, there
is little information on how SARS-CoV-2 affects metabolism. Using NMR spectroscopy, we …

Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts

P Würtz, AS Havulinna, P Soininen, T Tynkkynen… - Circulation, 2015 - Am Heart Assoc
Background—High-throughput profiling of circulating metabolites may improve
cardiovascular risk prediction over established risk factors. Methods and Results—We …

[HTML][HTML] Applications and prospects of cryo-EM in drug discovery

KF Zhu, C Yuan, YM Du, KL Sun, XK Zhang… - Military Medical …, 2023 - Springer
Drug discovery is a crucial part of human healthcare and has dramatically benefited human
lifespan and life quality in recent centuries, however, it is usually time-and effort-consuming …

Recent advances in NMR-based metabolomics

GA Nagana Gowda, D Raftery - Analytical Chemistry, 2017 - ACS Publications
NMR spectroscopy, one of the two major analytical platforms utilized in the metabolomics
field, has witnessed a large number of advances in fundamental studies, methods …

Metabolomics technology and bioinformatics for precision medicine

RK Azad, V Shulaev - Briefings in bioinformatics, 2019 - academic.oup.com
Precision medicine is rapidly emerging as a strategy to tailor medical treatment to a small
group or even individual patients based on their genetics, environment and lifestyle …

Comprehensive metabolomic profiling and incident cardiovascular disease: a systematic review

M Ruiz‐Canela, A Hruby, CB Clish… - Journal of the …, 2017 - Am Heart Assoc
Background Metabolomics is a promising tool of cardiovascular biomarker discovery. We
systematically reviewed the literature on comprehensive metabolomic profiling in …

Blood metabolite profiles linking dietary patterns with health—toward precision nutrition

S Noerman, R Landberg - Journal of Internal Medicine, 2023 - Wiley Online Library
Diet is one of the most important exposures that may affect health throughout life span.
Investigations on dietary patterns rather than single food components are gaining in …

[HTML][HTML] Association of circulating metabolites with healthy diet and risk of cardiovascular disease: analysis of two cohort studies

T Akbaraly, P Würtz, A Singh-Manoux, MJ Shipley… - Scientific reports, 2018 - nature.com
Diet may modify metabolomic profiles towards higher or lower cardiovascular disease (CVD)
risk. We aimed to identify metabolite profiles associated with high adherence to dietary …