Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Over the past 20 years, protein engineering has been extensively used to improve and
modify the fundamental properties of fluorescent proteins (FPs) with the goal of adapting …

Super-resolution fluorescence imaging by photoactivation or photoswitching of single
fluorophores and position determination (single-molecule localization microscopy, SMLM) …

Fluorescence microscopy is an invaluable tool in the biosciences, a genuine workhorse
technique offering exceptional contrast in conjunction with high specificity of labelling with …

Super-resolution microscopy has become an increasingly popular and robust tool across the
life sciences to study minute cellular structures and processes. However, with the increasing …

Rat sarcoma (Ras) GTPases regulate cell proliferation and survival through effector
pathways including Raf-MAPK, and are the most frequently mutated genes in human cancer …

Non-viral vehicles hold therapeutic promise in advancing the delivery of a variety of cargos
in vitro and in vivo, including small molecule drugs, biologics, and especially nucleic acids …

Complex protein networks are involved in nearly all cellular processes. To uncover these
vast networks of protein interactions, various high-throughput screening technologies have …

Metal nanoparticles can be sensitive molecular sensors due to enhanced absorption and
scattering of light near a localized surface plasmon resonance (LSPR). Variations in both …

Compartmentalized biochemical activities are essential to all cellular processes, but there is
no generalizable method to visualize dynamic protein activities in living cells at a resolution …