Propionate, a short-chain fatty acid, serves important roles in the human body. However, our
review of the current literature suggests that under certain conditions, excess levels of …

Summary The N 6-methyladenosine (m 6 A) RNA modification is used widely to alter the fate
of mRNAs. Here we demonstrate that the C. elegans writer METT-10 (the ortholog of mouse …

As a model organism that has helped revolutionize life sciences, Caenorhabditis elegans
has been increasingly used in nutrition research. Here we explore the tradeoffs between …

Current clinical trials are testing the life-extending benefits of the diabetes drug metformin in
healthy individuals without diabetes. However, the metabolic response of a non-diabetic …

Fiber intake is associated with a lower risk for Alzheimer´ s disease (AD) in older adults.
Intake of plant-based diets rich in soluble fiber promotes the production of short-chain fatty …

Summary Vitamin B12 (B12) deficiency is a critical problem worldwide. Such deficiency in
infants has long been known to increase the propensity to develop obesity and diabetes …

Mitochondria play a pivotal role in the generation of signals coupling metabolism with
neurotransmitter release, but a role for mitochondrial-produced ROS in regulating …

Deprivation of vitamin B12 (VB12) is linked to various diseases, but the underlying
mechanisms in disease progression are poorly understood. Using multiomic approaches …

Vitamin B12 (VB12) is a micronutrient that is essential for DNA synthesis and cellular energy
production. We recently demonstrated that VB12 oral supplementation coordinates ileal …

Healthy mitochondria are critical for reproduction. During aging, both reproductive fitness
and mitochondrial homeostasis decline. Mitochondrial metabolism and dynamics are key …