A comprehensive review of ethnopharmacology, phytochemistry, pharmacology, and pharmacokinetics of Schisandra chinensis (Turcz.) Baill. and Schisandra …

K Yang, J Qiu, Z Huang, Z Yu, W Wang, H Hu… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Schisandra chinensis (called bei-wuweizi in Chinese, S.
chinensis) and Schisandra sphenanthera (called nan-wuweizi in Chinese, S. sphenanthera) …

A review of polysaccharides from Schisandra chinensis and Schisandra sphenanthera: Properties, functions and applications

Z Li, X He, F Liu, J Wang, J Feng - Carbohydrate Polymers, 2018 - Elsevier
Schisandra is an herbal plant resource with dual functions in medicine and food since
ancient times. It has a variety of healthcare and therapeutic effects. Schisandra chinensis …

The therapeutic potential of plant polysaccharides in metabolic diseases

XF Wang, X Chen, Y Tang, JM Wu, DL Qin, L Yu… - Pharmaceuticals, 2022 - mdpi.com
Plant polysaccharides (PPS) composed of more than 10 monosaccharides show high safety
and various pharmacological activities, including immunoregulatory, antitumor …

[HTML][HTML] PXR triggers YAP-TEAD binding and Sirt2-driven YAP deacetylation and polyubiquitination to promote liver enlargement and regeneration in mice

S Zhang, M Guo, X Jiang, L Tang, T Wu, G Bi… - Pharmacological …, 2023 - Elsevier
Pregnane X receptor (PXR) plays an important role in the regulation of metabolic
homeostasis. Yes-associated protein (YAP) is a critical regulator of liver size and liver …

Schisandra sphenanthera: A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications

S Huang, D Zhang, Y Li, H Fan, Y Liu… - The American journal …, 2021 - World Scientific
Schisandra sphenanthera Rehd. et Wils (S. sphenanthera) is a single species of Schisandra
genus, Magnoliaceae family, and it is a famous medicinal herb mostly growing in southern …

Protective effects of menthol against sepsis-induced hepatic injury: Role of mediators of hepatic inflammation, apoptosis, and regeneration

AI Matouk, M El-Daly, HA Habib, S Senousy… - Frontiers in …, 2022 - frontiersin.org
Liver dysfunction in sepsis is a major complication that amplifies multiple organ failure and
increases the risk of death. Inflammation and oxidative stress are the main mediators in the …

UGT1A1 dysfunction increases liver burden and aggravates hepatocyte damage caused by long-term bilirubin metabolism disorder

D Liu, Q Yu, Z Li, L Zhang, M Hu, C Wang… - Biochemical pharmacology, 2021 - Elsevier
UGT1A1 is the only enzyme that can metabolize bilirubin, and its encoding gene is
frequently mutated. UGT1A1* 6 (G71R) is a common mutant in Asia which leads to the …

[HTML][HTML] Schisandra sphenanthera extract (Wuzhi Tablet) protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway …

X Zeng, X Li, C Xu, F Jiang, Y Mo, X Fan, Y Li… - … Pharmaceutica Sinica B, 2017 - Elsevier
Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.
Wuzhi Tablet (WZ), a preparation of extract from Schisandra sphenanthera that is a …

[HTML][HTML] The pharmacology and mechanisms of traditional Chinese medicine in promoting liver regeneration: a new therapeutic option

JT Ma, S Xia, BK Zhang, F Luo, L Guo, Y Yang, H Gong… - Phytomedicine, 2023 - Elsevier
Background The liver is renowned for its remarkable regenerative capacity to restore its
structure, size and function after various types of liver injury. However, in patients with end …

Schisandrol B promotes liver regeneration after partial hepatectomy in mice

X Li, J Sun, X Fan, L Guan, D Li, Y Zhou, X Zeng… - European Journal of …, 2018 - Elsevier
Liver regeneration is a vital process of recovery after liver damage, which is a promising
clinical strategy after partial hepatectomy (PHx). Schisandrol B (SolB), one of the bioactive …