Abstract Mitochondria contain about 1,000–1,500 proteins that fulfil multiple functions.
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …

Mitochondria are essential organelles that execute and coordinate various metabolic
processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes …

Mitochondria are central hubs of cellular metabolism that also play key roles in signaling
and disease. It is therefore fundamentally important that mitochondrial quality and activity …

The mitochondrial network is not only required for the production of energy, essential
cofactors and amino acids, but also serves as a signaling hub for innate immune and …

Accumulation of intracellular damage is an almost universal hallmark of aging. An improved
understanding of the systems that contribute to cellular protein quality control has shed light …

The dynamic coordination of processes controlling the quality of the mitochondrial network is
crucial to maintain the function of mitochondria in skeletal muscle. Changes of mitochondrial …

The transition metal iron is essential for life, yet potentially toxic iron-catalyzed reactive
oxygen species (ROS) are unavoidable in an oxygen-rich environment. Iron and ROS are …

The last decade has been marked by tremendous progress in our understanding of the cell
biology of mitochondria, with the identification of molecules and mechanisms that regulate …

The AAA+-type ATPase p97 governs an ever-expanding number of cellular processes
reaching from degradation of damaged proteins and organelles to key signaling events and …

Mitochondrial biogenesis and functions depend on the import of precursor proteins via the
'translocase of the outer membrane'(TOM complex). Defects in protein import lead to an …