Responses to drugs and pharmacological treatments differ considerably between
individuals. Importantly, only 50%–75% of patients have been shown to react adequately to …

Background: The global mortality from HIV and the cutaneous burden of infective,
inflammatory and malignant diseases in the setting of AIDS have significantly declined …

Human immunodeficiency virus (HIV)–infected South African patients (n= 468) received
blinded lamivudine or emtricitabine, stavudine, and either nevirapine or efavirenz (based on …

Incidence and etiology of acute renal failure among ambulatory HIV-infected patients.
Background Acute renal failure (ARF) is a cause of renal dysfunction in human …

Objective Investigation of a possible involvement of differences in human leukocyte antigens
(HLA) in the risk of nevirapine (NVP)-induced skin rash among HIV-infected patients …

Objective The relationships between adverse events (AEs) and plasma concentrations of
nevirapine (NVP) and efavirenz (EFV) were investigated as part of the large, international …

Background Despite the efficacy of combination antiretroviral therapy (ART) and the
improvement in prognosis of those living with HIV/AIDS, a large proportion of individuals on …

Several relationships have been reported between antiretroviral drug concentrations and
the efficacy of treatment, and toxicity. Therefore, therapeutic drug monitoring (TDM) may be a …

Objectives The aim of the study was to characterize the impact of the cytochrome P450 2B6
(CYP2B6), CYP3A4, CYP3A5 and ATP‐binding cassette sub‐family B member 1 (ABCB1) …

There is an increasing uptake of TDM of antiretroviral drugs, particularly in Europe. There is
consensus that current antiretroviral drugs meet most of the criteria of drugs that can be …