[HTML][HTML] Glycolysis in the control of blood glucose homeostasis
Glycolysis, a simple pathway of glucose metabolism, critically regulates insulin secretion
and metabolic functions of various cells. Depending on cell types, rates of glycolysis are …
and metabolic functions of various cells. Depending on cell types, rates of glycolysis are …
Metformin and metabolic diseases: a focus on hepatic aspects
Metformin has been widely used as a first-line anti-diabetic medicine for the treatment of
type 2 diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses …
type 2 diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses …
Expression of STING is increased in liver tissues from patients with NAFLD and promotes macrophage-mediated hepatic inflammation and fibrosis in mice
Background & Aims Transmembrane protein 173 (TMEM173 or STING) signaling by
macrophage activates the type I interferon-mediated innate immune response. The innate …
macrophage activates the type I interferon-mediated innate immune response. The innate …
De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health
L Eissing, T Scherer, K Tödter, U Knippschild… - Nature …, 2013 - nature.com
Clinical interest in de novo lipogenesis has been sparked by recent studies in rodents
demonstrating that de novo lipogenesis specifically in white adipose tissue produces the …
demonstrating that de novo lipogenesis specifically in white adipose tissue produces the …
Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in diet-induced obesity
Non-alcoholic fatty liver disease (NAFLD) is closely associated with obesity and insulin
resistance. To better understand the pathophysiology of obesity-associated NAFLD, the …
resistance. To better understand the pathophysiology of obesity-associated NAFLD, the …
First genome-wide association study of latent autoimmune diabetes in adults reveals novel insights linking immune and metabolic diabetes
OBJECTIVE Latent autoimmune diabetes in adults (LADA) shares clinical features with both
type 1 and type 2 diabetes; however, there is ongoing debate regarding the precise …
type 1 and type 2 diabetes; however, there is ongoing debate regarding the precise …
Palmitoleate induces hepatic steatosis but suppresses liver inflammatory response in mice
The interaction between fat deposition and inflammation during obesity contributes to the
development of non-alcoholic fatty liver disease (NAFLD). The present study examined the …
development of non-alcoholic fatty liver disease (NAFLD). The present study examined the …
Berberine ameliorates hepatic steatosis and suppresses liver and adipose tissue inflammation in mice with diet-induced obesity
Increasing evidence demonstrates that berberine (BBR) is beneficial for obesity-associated
non-alcoholic fatty liver disease (NAFLD). However, it remains to be elucidated how BBR …
non-alcoholic fatty liver disease (NAFLD). However, it remains to be elucidated how BBR …
Bariatric surgery-induced weight loss and associated genome-wide DNA-methylation alterations in obese individuals
FR Talukdar, DI Escobar Marcillo, RS Laskar… - Clinical …, 2022 - Springer
Background Obesity is a multifactorial and chronic condition of growing universal concern. It
has recently been reported that bariatric surgery is a more successful treatment for severe …
has recently been reported that bariatric surgery is a more successful treatment for severe …
The potential utility of PFKFB3 as a therapeutic target
R Bartrons, A Rodríguez-García… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: It has been known for over half a century that tumors exhibit an increased
demand for nutrients to fuel their rapid proliferation. Interest in targeting cancer metabolism …
demand for nutrients to fuel their rapid proliferation. Interest in targeting cancer metabolism …