Plants are an important source of chemically diverse natural products that target
microtubules, one of the most successful targets in cancer therapy. Colchicine, paclitaxel …

Covering: 2014–2019 We review recent progress on natural products that target cytoskeletal
components, including microtubules, actin, intermediate filaments, and septins and highlight …

The plant genus Tacca comprises twenty species including Tacca plantaginea, essentially
distributed in the Indo-China region. Medicinal preparations from the rhizomes are used …

Simple Summary Natural products have continued to play an important role in new drug
discovery with a considerable number of marketed drugs being derived from naturally …

The taccalonolide microtubule stabilizers covalently bind β-tubulin and overcome clinically
relevant taxane resistance mechanisms. Evaluations of the target specificity and detailed …

Cancer is the uncontrolled proliferation of abnormal cells that invade other areas, spread to
other organs, and cause metastases, which is the most common cause of death. A review of …

Ovarian cancer often has a poor clinical prognosis because of late detection, frequently after
metastatic progression, as well as acquired resistance to taxane-based therapy. Herein, we …

Seven highly oxidized steroids, taccachatrones A–G (1–7), together with four known
taccalonolides (8–11), were characterized from the rhizomes of Tacca chantrieri. The …

The taccalonolides are a class of microtubule stabilizers that circumvent clinically relevant
forms of drug resistance due to their unique mechanism of microtubule stabilization imparted …

Three new dimeric diarylheptanoids, taccachanfurans A–C (1–3), a new monomeric
diarylheptanoid, taccachannoid A (4), and four known diarylheptanoids (5–8) were isolated …