A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

Cisplatin and its platinum (Pt)(II) derivatives play a key role in the fight against various
human cancers such as testicular, ovarian, head and neck, lung tumors. However, their …

Cisplatin was one of the first chemotherapeutic agents to exhibit broad efficacy in solid
tumors and it remains among the most widely used agents in the treatment of cancer. Its …

Metal complexes of the type [Ni (LC) 2 (X) 2], 1 and 2,[Co (LC) 2 (X) 2], 3 and 4 (LC:
lidocaine, X= dca (dicyanamide), 1 and 3, X= NCS−, 2 and 4) have been synthesized and …

The tumour suppressor p53 is essential for maintaining DNA integrity, and plays a major role
in cellular senescence and aging. Understanding the mechanisms that contribute to p53 …

The new monofunctional Ru (II)-arene complex [(η6-arene) Ru (II)(en) Cl]+, where en= 1, 2-
diaminoethane and the arene is para-terphenyl (complex 1) exhibits promising cytotoxic …

The tumor suppressor p53 represents a paradigm for gene regulation. Its rapid induction in
response to DNA damage conditions has been attributed to both increased half-life of p53 …

Background The initial pharmacokinetic study of a new anticancer agent (OC-6-43)-bis
(acetato)(1-adamantylamine) amminedichloroplatinum (IV)(LA-12) was complemented by …

TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) can selectively trigger
apoptosis in various cancer cell types. However, many cancer cells are resistant to death …

Highlights•Novel magnetic monodisperse poly (glycidyl methacrylate) microspheres were
developed.•The particles were coated with poly (ethylene glycol) terminated by carboxyl …