Rationale: Beryllium continues to have a wide range of industrial applications. Exposure to
beryllium can lead to sensitization (BeS) and chronic beryllium disease (CBD). Objectives …

Cancer is known to be a multi-step process, which involves different stages including
initiation, promotion, progression and metastasis. Chemical carcinogens including most …

Chronic beryllium disease is an occupational lung disease that begins as a cell-mediated
immune response to beryllium. Although respiratory and engineering controls have …

Conventional materials technology has yielded clear improvements in regenerative
medicine. Ideally, however, a replacement material should mimic the living tissue …

The blood beryllium lymphocyte proliferation test is used in medical surveillance to identify
both beryllium sensitization and chronic beryllium disease. Approximately 50% of …

Beryllium exposure can cause a granulomatous lung disease in workers who develop a
lymphocyte-mediated sensitization to the metal. Workers in diverse industries are at risk …

A glutamic acid at residue 69 (Glu 69) in the HLA-DPB1 gene (Glu 69) is associated with
chronic beryllium disease (CBD) and possibly beryllium sensitization (BeS). This study …

Chronic beryllium disease (CBD) is a hypersensitivity granulomatosis characterized by
beryllium hypersensitivity (BH) and mediated by CD4+ T cells. However, all individuals with …

Materials and Methods: The criteria used in the current review for selecting articles were
adopted from proposed criteria in The International Classification of Functioning, Disability …

The human leukocyte antigen (HLA) complex is a series of genes located on chromosome 6
that are important in normal immune function. Susceptibility to chronic beryllium disease, a …