[HTML][HTML] Affinity maturation of antibody fragments: A review encompassing the development from random approaches to computational rational optimization

J Li, G Kang, J Wang, H Yuan, Y Wu, S Meng… - International journal of …, 2023 - Elsevier
Routinely screened antibody fragments usually require further in vitro maturation to achieve
the desired biophysical properties. Blind in vitro strategies can produce improved ligands by …

[HTML][HTML] Effective control of postoperative recurrence of pregnancy-related gastric cancer using anti-PD-1 as a monotherapy: a case report

X Liu, X Li, C Zhu, L Ji - Frontiers in Oncology, 2024 - ncbi.nlm.nih.gov
Pregnancy-related gastric cancer is characterized by a refractory nature and poor prognosis;
few gastric cancer cases during pregnancy achieved acceptable outcomes by using anti-PD …

Tissue‐type plasminogen activator (tPA) homozygous Tyr471His mutation associates with thromboembolic disease

Y Tao, J Ma, Y Feng, C Gao, T Wu, Y Xia, Z Cheng… - MedComm, 2023 - Wiley Online Library
Tissue‐type plasminogen activator (tPA) encoded by PLAT is a major mediator that
promotes fibrinolysis and prevents thrombosis. Pathogenetic mutations in PLAT associated …