Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
Enhancement of peripheral fatty acyl ethanolamide signaling prevents stress-induced social avoidance and anxiety-like behaviors in male rats
Rationale Exposure to traumatic events can lead to alterations in social and anxiety-related
behaviors. Emerging evidence suggests that peripheral host-defense processes are …
behaviors. Emerging evidence suggests that peripheral host-defense processes are …
Fatty acid amide hydrolase inhibition alleviates anxiety-like symptoms in a rat model used to study post-traumatic stress disorder
Background and aim Post-traumatic stress disorder (PTSD), a chronic debilitating condition
that affects nearly 5–10% of American adults, is treated with a handful of FDA-approved …
that affects nearly 5–10% of American adults, is treated with a handful of FDA-approved …
[HTML][HTML] Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent pain
S Nobili, L Micheli, E Lucarini, A Toti… - Pharmacology & …, 2024 - Elsevier
Current epidemiological data estimate that one in five people suffers from chronic pain with
considerable impairment of health-related quality of life. The pharmacological treatment is …
considerable impairment of health-related quality of life. The pharmacological treatment is …
Lysosome targeting fluorescent probe for NAAA imaging and its applications in the drug development for anti-inflammatory
L Zhou, M Tian, B Zhang, X Cao, X Huo, F Yang… - International Journal of …, 2024 - Elsevier
N-acylethanolamine acid amidase (NAAA) is a nucleophilic lysosomal cysteine hydrolase,
which primarily mediates the hydrolytic inactivation of endogenous palmitoylethanolamide …
which primarily mediates the hydrolytic inactivation of endogenous palmitoylethanolamide …
α-Acylamino-β-lactone N-Acylethanolamine-hydrolyzing Acid Amidase Inhibitors Encapsulated in PLGA Nanoparticles: Improvement of the Physical Stability and …
N-Acylethanolamine acid amidase (NAAA) is an N-terminal cysteine hydrolase that
preferentially catalyzes the hydrolysis of endogenous lipid mediators such as …
preferentially catalyzes the hydrolysis of endogenous lipid mediators such as …
NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice
Y Fotio, A Mabou Tagne, E Squire, H Lee… - Nature …, 2024 - nature.com
Circulating monocytes participate in pain chronification but the molecular events that cause
their deployment are unclear. Using a mouse model of hyperalgesic priming (HP), we show …
their deployment are unclear. Using a mouse model of hyperalgesic priming (HP), we show …
Genetic blockade of NAAA cell-specifically regulates fatty acid ethanolamides (FAEs) metabolism and inflammatory responses
N-Acylethanolamine acid amidase (NAAA) is a lysosomal enzyme responsible for the
hydrolysis of fatty acid ethanolamides (FAEs). However, the role of NAAA in FAEs …
hydrolysis of fatty acid ethanolamides (FAEs). However, the role of NAAA in FAEs …
Δ9-Tetrahydrocannabinol alleviates hyperalgesia in a humanized mouse model of sickle cell disease
People with sickle cell disease (SCD) often experience chronic pain as well as
unpredictable episodes of acute pain, which significantly affects their quality of life and life …
unpredictable episodes of acute pain, which significantly affects their quality of life and life …