Vitamin in the crosshairs: targeting pantothenate and coenzyme a biosynthesis for new antituberculosis agents
HS Butman, TJ Kotzé, CS Dowd… - Frontiers in Cellular and …, 2020 - frontiersin.org
Despite decades of dedicated research, there remains a dire need for new drugs against
tuberculosis (TB). Current therapies are generations old and problematic. Resistance to …
tuberculosis (TB). Current therapies are generations old and problematic. Resistance to …
Thiazolyl-pyrazole derivatives as potential antimycobacterial agents
SJ Takate, AD Shinde, BK Karale, H Akolkar… - Bioorganic & Medicinal …, 2019 - Elsevier
Mycobacterium tuberculosis (Mtb) is an obligate aerobe that is capable of long-term
persistence under conditions of low oxygen tension. A series of thiazolyl-pyrazole …
persistence under conditions of low oxygen tension. A series of thiazolyl-pyrazole …
Predictive Power of In Silico Approach to Evaluate Chemicals against M. tuberculosis: A Systematic Review
Mycobacterium tuberculosis (Mtb) is an endemic bacterium worldwide that causes
tuberculosis (TB) and involves long-term treatment that is not always effective. In this context …
tuberculosis (TB) and involves long-term treatment that is not always effective. In this context …
Pentafuhalol-B, a Phlorotannin from Brown Algae, Strongly Inhibits the PLK-1 Overexpression in Cancer Cells as Revealed by Computational Analysis
WA Ansari, SO Rab, M Saquib, A Sarfraz, MK Hussain… - Molecules, 2023 - mdpi.com
Polo-like kinase-1 (PLK-1) is an essential mitotic serine/threonine (Ser/Thr) kinase that
belongs to the Polo-like kinase (PLK) family and is overexpressed in non-small cell lung …
belongs to the Polo-like kinase (PLK) family and is overexpressed in non-small cell lung …
Exploring the Pharmacological Potentials of Biosurfactant Derived from Planococcus maritimus SAMP MCC 3013
Therapeutic potential of biosurfactant (BS) has been improved in recent years. Our present
study deals with production of BS from Planococcus maritimus SAMP MCC 3013 in a …
study deals with production of BS from Planococcus maritimus SAMP MCC 3013 in a …
Evaluation of the antiviral potential of halogenated dihydrorugosaflavonoids and molecular modeling with nsP3 protein of Chikungunya virus (CHIKV)
Antiviral therapy is crucial for the circumvention of viral epidemics. The unavailability of a
specific antiviral drug against the chikungunya virus (CHIKV) disease has created an …
specific antiviral drug against the chikungunya virus (CHIKV) disease has created an …
Identification of isobavachalcone as a potential drug for rice blast disease caused by the fungus Magnaporthe grisea
The rice blast disease caused by the fungus Magnaporthe grisea is one of the most
devastating rice diseases, but there is no effective fungicide toward chitinase which is a key …
devastating rice diseases, but there is no effective fungicide toward chitinase which is a key …
Design, Synthesis, and in vitro Biological Evaluation of ROS‐Generating Phenanthridin‐trione‐Epoxide Conjugates as Agents against Mycobacterium tuberculosis
Tuberculosis (TB) is one of the devasting infectious diseases and continues to spread
among people despite having several specific drugs. Total eradication of TB is one of the …
among people despite having several specific drugs. Total eradication of TB is one of the …
Identification of Pyruvate Dehydrogenase E1 as a Potential Target against Magnaporthe oryzae through Experimental and Theoretical Investigation
Y Li, B Hu, Z Wang, J He, Y Zhang, J Wang… - International Journal of …, 2021 - mdpi.com
Magnaporthe oryzae (M. oryzae) is a typical cause of rice blast in agricultural production.
Isobavachalcone (IBC), an active ingredient of Psoralea corylifolia L. extract, is an effective …
Isobavachalcone (IBC), an active ingredient of Psoralea corylifolia L. extract, is an effective …
The first synthesis of podocarflavone A and its analogs and evaluation of their antimycobacterial potential against Mycobacterium tuberculosis with the support of …
The first synthetic route developed for Podocarflavone A reported from Podocarpus
macrophyllus and its analogs in 7 steps. Computational analysis for binding with the …
macrophyllus and its analogs in 7 steps. Computational analysis for binding with the …