Preterm brain injury, antenatal triggers, and therapeutics: timing is key

DRMG Ophelders, R Gussenhoven, L Klein… - Cells, 2020 - mdpi.com
With a worldwide incidence of 15 million cases, preterm birth is a major contributor to
neonatal mortality and morbidity, and concomitant social and economic burden Preterm …

Neonatal encephalopathy: Etiologies other than hypoxic-ischemic encephalopathy

AGS Karamian, S Mercimek-Andrews… - Seminars in Fetal and …, 2021 - Elsevier
Neonatal encephalopathy (NE) describes the clinical syndrome of a newborn with abnormal
brain function that may result from a variety of etiologies. HIE should be distinguished from …

Novel interventions to reduce oxidative-stress related brain injury in neonatal asphyxia

AL Solevåg, GM Schmölzer, PY Cheung - Free Radical Biology and …, 2019 - Elsevier
Perinatal asphyxia-induced brain injury may present as hypoxic-ischemic encephalopathy in
the neonatal period, and disability including cerebral palsy in the long term. The brain injury …

Animal models for neonatal brain injury induced by hypoxic ischemic conditions in rodents

N Hamdy, S Eide, HS Sun, ZP Feng - Experimental Neurology, 2020 - Elsevier
Neonatal hypoxia-ischemia and resulting encephalopathies are of significant concern.
Intrapartum asphyxia is a leading cause of neonatal death globally. Among surviving infants …

Management of multi organ dysfunction in neonatal encephalopathy

M O'Dea, D Sweetman, SL Bonifacio, M El-Dib… - Frontiers in …, 2020 - frontiersin.org
Neonatal Encephalopathy (NE) describes neonates with disturbed neurological function in
the first post-natal days of life. NE is an overall term that does not specify the etiology of the …

White matter injury in the neonatal hypoxic‐ischemic brain and potential therapies targeting microglia

R Shao, D Sun, Y Hu, D Cui - Journal of Neuroscience …, 2021 - Wiley Online Library
Neonatal hypoxic–ischemic (H‐I) injury, which mainly causes neuronal damage and white
matter injury (WMI), is among the predominant causes of infant morbidity (cerebral palsy …

Current therapies for neonatal hypoxic–ischaemic and infection-sensitised hypoxic–ischaemic brain damage

K Tetorou, C Sisa, A Iqbal, K Dhillon… - Frontiers in synaptic …, 2021 - frontiersin.org
Neonatal hypoxic–ischaemic brain damage is a leading cause of child mortality and
morbidity, including cerebral palsy, epilepsy, and cognitive disabilities. The majority of …

Temporal Characterization of Microglia‐Associated Pro‐and Anti‐Inflammatory Genes in a Neonatal Inflammation‐Sensitized Hypoxic‐Ischemic Brain Injury Model

ME Bernis, Y Schleehuber, M Zweyer… - Oxidative medicine …, 2022 - Wiley Online Library
Hypoxic‐ischemic encephalopathy (HIE) mainly affects preterm and term newborns, leading
to a high risk of brain damage. Coexisting infection/inflammation and birth asphyxia are key …

Unanswered questions regarding therapeutic hypothermia for neonates with neonatal encephalopathy

H Sabir, SL Bonifacio, AJ Gunn, M Thoresen… - Seminars in Fetal and …, 2021 - Elsevier
Therapeutic hypothermia (TH) is now well established to improve intact survival after
neonatal encephalopathy (NE). However, many questions could not be addressed by the …

Neonatal encephalopathy with group B streptococcal disease worldwide: systematic review, investigator group datasets, and meta-analysis

CJ Tann, KA Martinello, S Sadoo… - Clinical Infectious …, 2017 - academic.oup.com
Background Neonatal encephalopathy (NE) is a leading cause of child mortality and longer-
term impairment. Infection can sensitize the newborn brain to injury; however, the role of …