Sumatriptan is the first available medication from triptans family that was approved by the US
Food and Drug Administration for migraine attacks and cluster headaches in 1991. Most of …

Chloroquine (CQ) is an antimalarial drug that elicits severe pruritus in black Africans with
malaria fever. This acute itching (2–7 days duration) exhibits age dependency and a racial …

Acupuncture has been known to be effective for atopic dermatitis, especially ameliorating
itch; however, its mechanisms are still unclear. The aim of this study was to test the anti-itch …

Ischemic heart disease is a leading cause of death on a global scale, placing major socio-
economic burdens on health systems worldwide. Myocardial ischaemia and reperfusion …

Mucosal inflammation in colitis is associated with changes in the intestinal serotonin (5-HT)
level. Sumatriptan, a 5‐HT1B/1D receptor agonist, has demonstrated anti-inflammatory …

Objectives To investigate the therapeutic effects of sumatriptan in a rat model of spinal cord
injury (SCI) and possible anti-inflammatory and analgesic mechanisms underlying this …

The clinical use of doxorubicin as a potent chemotherapeutic agent is limited due to its
dosedependent cardiotoxicity. Oxidative stress and inflammatory pathways have a pivotal …

Background Early post-stroke seizure frequently occurs in stroke survivors within the first few
days and is associated with poor functional outcomes. Therefore, efficient treatments of such …

Background Mesenteric ischemia has remained without effective pharmacological
management for many years. Sumatriptan, an abortive medication for migraine and cluster …

Pruritus is an uncomfortable sensation induced by various pruritogens, including serotonin.
Serotonin, acting as an inflammatory mediator, can activate a histamine-independent …