An acute ischaemic stroke is due to the sudden blockage of an intracranial blood vessel by
an embolized thrombus. In the context of setting up in silico trials for the treatment of acute …

The advancement of ischaemic stroke treatment relies on resource-intensive experiments
and clinical trials. In order to improve ischaemic stroke treatments, such as thrombolysis and …

Macro-vascular artifacts are a common arterial spin labeling (ASL) finding in populations
with prolonged arterial transit time (ATT) and result in vascular regions with spuriously …

Cerebral perfusion modelling is a promising tool to predict the impact of acute ischaemic
stroke treatments on the spatial distribution of cerebral blood flow (CBF) in the human brain …

Accumulating evidence suggests vascular dysregulation in preclinical Alzheimer's disease.
In this study, cerebral hemodynamics and their coupling with cognition in middle-aged …

Purpose To investigate whether measurement of arterial transit time (ATT) can improve the
accuracy of arterial spin labeling (ASL) cerebral blood flow (CBF) quantification in an elderly …

Calibrated fMRI based on arterial spin-labeling (ASL) and blood oxygen-dependent contrast
(BOLD), combined with periods of hypercapnia and hyperoxia, can provide information on …

Perivascular spaces (PVSs) are fluid-filled spaces surrounding penetrating blood vessels in
the brain and are an integral pathway of the glymphatic system. A PVS and the enclosed …

Computational physiological models are promising tools to enhance the design of clinical
trials and to assist in decision making. Organ-scale haemodynamic models are gaining …

Micro-or macro-circulatory insufficiency has a negative impact in patients with Alzheimer's
disease (AD). This study used arterial spin-labeled magnetic resonance imaging (ASL-MRI) …