Mapping human brain lesions and their functional consequences

HO Karnath, C Sperber, C Rorden - Neuroimage, 2018 - Elsevier
Neuroscience has a long history of inferring brain function by examining the relationship
between brain injury and subsequent behavioral impairments. The primary advantage of this …

Mapping correlated neurological deficits after stroke to distributed brain networks

JS Siegel, GL Shulman, M Corbetta - Brain Structure and Function, 2022 - Springer
Understanding the relationships between brain organization and behavior is a central goal
of neuroscience. Traditional teaching emphasizes that the human cerebrum includes many …

Advanced lesion symptom mapping analyses and implementation as BCBtoolkit

C Foulon, L Cerliani, S Kinkingnehun, R Levy… - …, 2018 - academic.oup.com
Background Patients with brain lesions provide a unique opportunity to understand the
functioning of the human mind. However, even when focal, brain lesions have local and …

Post-stroke outcomes predicted from multivariate lesion-behaviour and lesion network mapping

M Bowren Jr, J Bruss, K Manzel, D Edwards, C Liu… - Brain, 2022 - academic.oup.com
Clinicians and scientists alike have long sought to predict the course and severity of chronic
post-stroke cognitive and motor outcomes, as the ability to do so would inform treatment and …

Structural disconnections explain brain network dysfunction after stroke

JC Griffis, NV Metcalf, M Corbetta, GL Shulman - Cell reports, 2019 - cell.com
Stroke causes focal brain lesions that disrupt functional connectivity (FC), a measure of
activity synchronization, throughout distributed brain networks. It is often assumed that FC …

Assessing and mapping language, attention and executive multidimensional deficits in stroke aphasia

R Schumacher, AD Halai, MA Lambon Ralph - Brain, 2019 - academic.oup.com
There is growing awareness that aphasia following a stroke can include deficits in other
cognitive functions and that these are predictive of certain aspects of language function …

[HTML][HTML] Lesion Quantification Toolkit: A MATLAB software tool for estimating grey matter damage and white matter disconnections in patients with focal brain lesions

JC Griffis, NV Metcalf, M Corbetta, GL Shulman - NeuroImage: Clinical, 2021 - Elsevier
Lesion studies are an important tool for cognitive neuroscientists and neurologists. However,
while brain lesion studies have traditionally aimed to localize neurological symptoms to …

[HTML][HTML] The impact of epilepsy surgery on the structural connectome and its relation to outcome

PN Taylor, N Sinha, Y Wang, SB Vos, J de Tisi… - NeuroImage: Clinical, 2018 - Elsevier
Background Temporal lobe surgical resection brings seizure remission in up to 80% of
patients, with long-term complete seizure freedom in 41%. However, it is unclear how …

White matter tract density index prediction model of overall survival in Glioblastoma

A Salvalaggio, L Pini, M Gaiola, A Velco… - JAMA …, 2023 - jamanetwork.com
Importance The prognosis of overall survival (OS) in patients with glioblastoma (GBM) may
depend on the underlying structural connectivity of the brain. Objective To examine the …

Machine learning‐based multimodal prediction of language outcomes in chronic aphasia

S Kristinsson, W Zhang, C Rorden… - Human brain …, 2021 - Wiley Online Library
Recent studies have combined multiple neuroimaging modalities to gain further
understanding of the neurobiological substrates of aphasia. Following this line of work, the …