Recent advances in microfluidics have enabled the molecular-level study of polymer
dynamics using single DNA chains. Single polymer studies based on fluorescence …

Engineering using liquids confined in channels 10− 1000 nm in dimension, or “extended-
nanofluidics,” is the next target of microfluidic science. Liquid properties at this scale were …

The trajectories of nanoscale particles through microscale environments record useful
information about both the particles and the environments. Optical microscopes provide …

The electrophoretically driven transport of double-stranded λ-phage DNA through focused
ion beam (FIB) milled nanochannels is described. Nanochannels were fabricated having …

We demonstrate a new platform, convex lens-induced nanoscale templating (CLINT), for
dynamic manipulation and trapping of single DNA molecules. In the CLINT technique, the …

The wormlike-chain model is commonly used to describe the statistical properties of DNA
and liquid-crystal polymers. Following the Green's function approach, here we present the …

Confinement of single molecules within nanoscale environments is crucial in a range of
fields, including biomedicine, genomics, and biophysics. Here, we present a method that …

We directly measure the free energy of confinement for semiflexible polymers from the
nanoscale to bulk regimes in slit-like confinement. We use convex lens-induced confinement …

Within a confining tube section, the multithreads of a strongly confined, backfolding polymer
exert the excluded-volume repulsions on each other and produce physical properties that …

We investigate the conformation and relaxation dynamics of single DNA molecules in strong
confinement (smaller than persistence length) with coarse-grained semiflexible chain (SFC) …