Gastrointestinal symptoms associated with COVID-19: impact on the gut microbiome

S Villapol - Translational Research, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the
greatest worldwide pandemic since the 1918 flu. The consequences of the coronavirus …

ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities–role of gut microbiota dysbiosis

SD Viana, S Nunes, F Reis - Ageing research reviews, 2020 - Elsevier
Abstract Coronavirus disease 19 (COVID-19) is a pandemic condition caused by the new
coronavirus SARS-CoV-2. The typical symptoms are fever, cough, shortness of breath …

Imbalance of the renin–angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

M Garg, SG Royce, C Tikellis, C Shallue, D Batu… - Gut, 2020 - gut.bmj.com
Objective We evaluated the influence of the renin–angiotensin system (RAS) on intestinal
inflammation and fibrosis. Design Cultured human colonic myofibroblast proliferation and …

Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability

K de Punder, L Pruimboom - Frontiers in immunology, 2015 - frontiersin.org
Chronic non-communicable diseases (NCDs) are the leading causes of work absence,
disability, and mortality worldwide. Most of these diseases are associated with low-grade …

Angiotensin II type I receptor (AT1R): the gate towards COVID-19-associated diseases

G El-Arif, S Khazaal, A Farhat, J Harb, C Annweiler… - Molecules, 2022 - mdpi.com
The binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike
glycoprotein to its cellular receptor, the angiotensin-converting enzyme 2 (ACE2), causes its …

[HTML][HTML] COVID-19 as a trigger of irritable bowel syndrome: A review of potential mechanisms

CR Settanni, G Ianiro, FR Ponziani… - World journal of …, 2021 - ncbi.nlm.nih.gov
In December 2019 a novel coronavirus disease 2019 (COVID-19), caused by the severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2), started spreading from Wuhan city …

Gut microbiota and renin-angiotensin system: A complex interplay at local and systemic levels

K Jaworska, M Koper, M Ufnal - American Journal of …, 2021 - journals.physiology.org
Gut microbiota is a potent biological modulator of many physiological and pathological
states. The renin-angiotensin system (RAS), including the local gastrointestinal RAS (GI …

A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme

KE Bernstein, FS Ong, WLB Blackwell, KH Shah… - Pharmacological …, 2013 - ASPET
Angiotensin-converting enzyme (ACE) is a zinc-dependent peptidase responsible for
converting angiotensin I into the vasoconstrictor angiotensin II. However, ACE is a relatively …

Malnutrition and dietary habits alter the immune system which may consequently influence SARS-CoV-2 virulence: a review

A Foolchand, T Ghazi, AA Chuturgoon - International Journal of …, 2022 - mdpi.com
COVID-19, resulting from the SARS-CoV-2 virus, is a major pandemic that the world is
fighting. SARS-CoV-2 primarily causes lung infection by attaching to the ACE2 receptor on …

Changes to the gut microbiota induced by losartan contributes to its antihypertensive effects

I Robles‐Vera, M Toral… - British Journal of …, 2020 - Wiley Online Library
Background and Purpose Hypertension is associated with gut dysbiosis. Here we have
evaluated the effects of the angiotensin receptor antagonist losartan on gut microbiota in …