Accurate predictions of the three-dimensional structures of proteins from their amino acid
sequences have come of age. AlphaFold, a deep learning-based approach to protein …

In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …

The AlphaFold Protein Structure Database contains predicted structures for millions of
proteins. For the majority of human proteins that contain intrinsically disordered regions …

Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …

The molecular machinery that enables life has evolved in water, yet many of the organisms
around us are able to survive even extreme desiccation. Especially remarkable are single …

Highlights•Compositions of IDPs fall into distinct classes.•Compositional classes encode
preferences for distinct conformational classes.•Functions of disordered proteins are …

Intrinsically disordered regions (IDRs) are ubiquitous across all domains of life and play a
range of functional roles. While folded domains are generally well-described by a stable 3D …

Intrinsically disordered regions make up a large part of the proteome, but the sequence-to-
function relationship in these regions is poorly understood, in part because the primary …

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β
family (TGFβ), which signal through hetero-tetrameric complexes of type I and type II …

Intrinsically disordered proteins (IDPs), which lack persistent structure, are a challenge to
structural biology due to the inapplicability of standard methods for characterization of folded …