Phosphatidylinositol-specific phospholipase Cγ2 (PLCγ2) is a critical signaling molecule
activated downstream from a variety of cell surface receptors that contain an intracellular …

Background Alzheimer's disease (AD) is characterized by robust microgliosis and
phenotypic changes that accompany disease pathogenesis. Accumulating evidence from …

Phospholipase Cγ1 (PLC-γ1), a tyrosine kinase substrate, is a multi-domain molecule that
modulates the intracellular levels of the second messenger molecules: Ca2+ and …

Alzheimer's disease (AD) is a complex neurodegenerative disorder involving heterogenous
pathophysiological characteristics, which has become a challenge to therapeutics. The …

Widespread, debilitating and often treatment-resistant, depression and other stress-related
neuropsychiatric disorders represent an urgent unmet biomedical and societal problem …

Alzheimer's disease (AD) is characterized by robust microgliosis and phenotypic changes
that accompany disease pathogenesis. Indeed, genetic variants in microglial genes are …

Obesity is recognized as a significant risk factor for Alzheimer's disease (AD). Studies have
supported the notion that obesity accelerates AD-related pathophysiology in mouse models …

Alzheimer's disease is a common and devastating age-related disease with no effective
disease-modifying treatments. Human genetics has implicated a wide range of cell surface …

Abstract Oligodendrocyte: oligodendrocyte (O: O) gap junction (GJ) coupling is a
widespread and essential feature of the CNS, and is mediated by connexin47 (Cx47) and …

Neurotrophic factors are essential neurone survival promoting molecules that are often
secreted and that bind to neuronal cell surface receptors. Glial cell line-derived neurotrophic …