Diffusion and Flux Improvement of Drugs through Complexation
Improving the solubility and permeability of drugs via cocrystallization is an important theme
in crystal engineering with practical applications for the discovery and development of high …
in crystal engineering with practical applications for the discovery and development of high …
Crystallinity: A Complex Critical Quality Attribute of Amorphous Solid Dispersions
DE Moseson, LS Taylor - Molecular Pharmaceutics, 2023 - ACS Publications
Does the performance of an amorphous solid dispersion rely on having 100% amorphous
content? What specifications are appropriate for crystalline content within an amorphous …
content? What specifications are appropriate for crystalline content within an amorphous …
Particle Size, Dose, and Confinement Affect Passive Diffusion Flux through the Membrane Concentration Boundary Layer
The authors present a steady-state-, particle-size-, and dose-dependent dissolution–
permeation model that describes particle dissolution within the concentration boundary layer …
permeation model that describes particle dissolution within the concentration boundary layer …
Quantitative Investigation of Intestinal Drug Absorption Enhancement by Drug-Rich Nanodroplets Generated via Liquid–Liquid Phase Separation
Drug-rich droplets formed through liquid–liquid phase separation (LLPS) have the potential
to enhance the oral absorption of drugs. This can be attributed to the diffusion of these …
to enhance the oral absorption of drugs. This can be attributed to the diffusion of these …
Predicting nanocarrier permeation across the human intestine in vitro: Model matters
N Jung, J Schreiner, F Baur, S Vogel-Kindgen… - bioRxiv, 2024 - biorxiv.org
For clinical translation of oral nanocarriers, simulation of the complex intestinal
microenvironment is crucial to evaluate interactions and transport across the intestinal …
microenvironment is crucial to evaluate interactions and transport across the intestinal …
A PEGylated Nanocarrier for Oral Delivery of Immunomodulator Thymopentin
MM Liu - 2023 - researchspace.auckland.ac.nz
The oral delivery of drugs is the most popular route of administration for patients. However,
thymopentin (TP5) is only available in the market in forms for parenteral administration as an …
thymopentin (TP5) is only available in the market in forms for parenteral administration as an …