Exosomes, a nano-sized subtype of extracellular vesicles secreted from almost all living
cells, are capable of transferring cell-specific constituents of the source cell to the recipient …

Newly endocytosed integral cell surface proteins are typically either directed for degradation
or subjected to recycling back to the plasma membrane. The sorting of integral cell surface …

Autophagy and autophagy-related genes (Atg) have been attributed prominent roles in
tumorigenesis, tumor growth, and metastasis. Extracellular vesicles called exosomes are …

Lysosomes are the primary catabolic compartments of eukaryotic cells. They degrade
extracellular material that has been internalized by endocytosis and intracellular …

Live-cell imaging reveals the endolysosomal system as a complex and highly dynamic
network of interacting compartments. Distinct types of endosomes are discerned by kinetic …

When internalized receptors and other cargo are destined for lysosomal degradation, they
are ubiquitinated and sorted by the endosomal sorting complex required for transport …

The endosomal sorting complexes required for transport (ESCRTs) catalyse one of the most
unusual membrane remodelling events in cell biology. ESCRT-I and ESCRT-II direct …

Multivesicular bodies (MVBs) are unique organelles in the endocytic pathway that contain
vesicles in their lumen. Sorting and incorporation of material into such vesicles is a critical …

When wounded, eukaryotic cells reseal in a few seconds. Ca 2+ influx induces exocytosis of
lysosomes, a process previously thought to promote repair by 'patching'wounds. New …

The two major cellular sites for membrane protein degradation are the proteasome and the
lysosome. Ubiquitin attachment is a sorting signal for both degradation routes. For lysosomal …