Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by
removing acetyl groups from histones and other protein regulatory factors, with functional …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Normal hematopoiesis requires the accurate orchestration of lineage-specific patterns of
gene expression at each stage of development, and epigenetic regulators play a vital role …

Epigenetic changes associated with histone modifications play an important role in the
emergence and maintenance of the phenotype of various cancer types. In contrast to direct …

Zinc binding groups (ZBGs) play a crucial role in targeting histone deacetylase inhibitors
(HDACIs) to the active site of histone deacetylases (HDACs), thus determining the potency …

Histone deacetylases (HDACs) are expressed at increased levels in cells of various
malignancies, and the use of HDAC inhibitors has improved outcomes in patients with …

This review classifies drug‐design strategies successfully implemented in the development
of histone deacetylase (HDAC) inhibitors, which have many applications including cancer …

Sepsis is known since the time (470 BC) of great Greek physician, Hippocrates.
Advancement in modern medicine and establishment of separate branches of medical …

Abstract Purpose: Histone deacetylase inhibitors (HDACi) are promising anticancer drugs.
Although some HDACi have entered the clinic, the mechanism (s) underlying their tumor …

Preservation quality of donor hearts is a key determinant of transplant success. Preservation
duration beyond 4 hours is associated with primary graft dysfunction (PGD). Given transport …