The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential
GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - ASPET
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …
review, the different subtypes of voltage-gated calcium channels are described and their …
Neuronal voltage-gated calcium channels: structure, function, and dysfunction
BA Simms, GW Zamponi - Neuron, 2014 - cell.com
Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …
Targeting voltage-gated calcium channels in neurological and psychiatric diseases
GW Zamponi - Nature reviews Drug discovery, 2016 - nature.com
Voltage-gated calcium channels are important regulators of brain, heart and muscle
functions, and their dysfunction can give rise to pathophysiological conditions ranging from …
functions, and their dysfunction can give rise to pathophysiological conditions ranging from …
Loss of Cav1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness
SM Baig, A Koschak, A Lieb, M Gebhart… - Nature …, 2011 - nature.com
Deafness is genetically very heterogeneous and forms part of several syndromes. So far,
delayed rectifier potassium channels have been linked to human deafness associated with …
delayed rectifier potassium channels have been linked to human deafness associated with …
L‐type Ca2+ channels in heart and brain
J Striessnig, A Pinggera, G Kaur… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
L‐type calcium channels (Cav1) represent one of the three major classes (Cav1–3) of
voltage‐gated calcium channels. They were identified as the target of clinically used calcium …
voltage‐gated calcium channels. They were identified as the target of clinically used calcium …
[HTML][HTML] Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment
SB Sartori, N Whittle, A Hetzenauer, N Singewald - Neuropharmacology, 2012 - Elsevier
Preclinical and some clinical studies suggest a relationship between perturbation in
magnesium (Mg2+) homeostasis and pathological anxiety, although the underlying …
magnesium (Mg2+) homeostasis and pathological anxiety, although the underlying …
Genetic associations between voltage-gated calcium channels and psychiatric disorders
Psychiatric disorders are mental, behavioral or emotional disorders. These conditions are
prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has …
prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has …
Ion channels controlling circadian rhythms in suprachiasmatic nucleus excitability
JRM Harvey, AE Plante… - Physiological …, 2020 - journals.physiology.org
Animals synchronize to the environmental day-night cycle by means of an internal circadian
clock in the brain. In mammals, this timekeeping mechanism is housed in the …
clock in the brain. In mammals, this timekeeping mechanism is housed in the …
Role of TREK-1 in health and disease, focus on the central nervous system
A Djillani, J Mazella, C Heurteaux… - Frontiers in …, 2019 - frontiersin.org
TREK-1 is the most studied background K2P channel. Its main role is to control cell
excitability and maintain the membrane potential below the threshold of depolarization …
excitability and maintain the membrane potential below the threshold of depolarization …
Voltage-gated calcium channels: key players in sensory coding in the retina and the inner ear
T Pangrsic, JH Singer, A Koschak - Physiological reviews, 2018 - journals.physiology.org
Calcium influx through voltage-gated Ca (CaV) channels is the first step in synaptic
transmission. This review concerns CaV channels at ribbon synapses in primary sense …
transmission. This review concerns CaV channels at ribbon synapses in primary sense …