Drug Selection and Posology, Optimal Therapies and Risk/Benefit Assessment in Medicine: The Paradigm of Iron-Chelating Drugs
GJ Kontoghiorghes - International Journal of Molecular Sciences, 2023 - mdpi.com
The design of clinical protocols and the selection of drugs with appropriate posology are
critical parameters for therapeutic outcomes. Optimal therapeutic protocols could ideally be …
critical parameters for therapeutic outcomes. Optimal therapeutic protocols could ideally be …
Development of Mycobacterium tuberculosis Enoyl Acyl Reductase (InhA) Inhibitors: A Mini-Review
This review article delves into the critical role of Enoyl acyl carrier protein reductase (InhA;
ENR), a vital enzyme in the NADH-dependent acyl carrier protein reductase family …
ENR), a vital enzyme in the NADH-dependent acyl carrier protein reductase family …
Impacts of hydrophobic mismatch on antimicrobial peptide efficacy and bilayer permeabilization
S Meier, ZM Ridgway, AL Picciano, GA Caputo - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance continues to be a major threat to world health, with the continued
emergence of resistant bacterial strains. Antimicrobial peptides have emerged as an …
emergence of resistant bacterial strains. Antimicrobial peptides have emerged as an …
Investigating the anti-growth, anti-resistance, and anti-virulence activities of Schoepfia schreberi JF Gmel. against the superbug Acinetobacter baumannii
AH Uc-Cachón, A Dzul-Beh, M González-Cortázar… - Heliyon, 2024 - cell.com
Schoepfia schreberi has been used in Mayan folk medicine to treat diarrhea and cough. This
study aimed to determine the anti-growth, anti-resistance, and/or anti-virulence activities of …
study aimed to determine the anti-growth, anti-resistance, and/or anti-virulence activities of …
Synergistic Activity of Ingulados Bacteria with Antibiotics against Multidrug-Resistant Pathogens
J Blanco-Blanco, M Bravo, I Simón, P Fernández-Llario… - Antibiotics, 2024 - mdpi.com
Antimicrobial resistance is a critical challenge due to the overuse of conventional
antimicrobials, and alternative solutions are urgently needed. This study investigates the …
antimicrobials, and alternative solutions are urgently needed. This study investigates the …
α-Pyrones: Natural Occurrence, Chemistry, and Biological Approaches—An Update
M Azizian, S Gheshlaghi, A Danesh… - Revista Brasileira de …, 2024 - Springer
Abstract α-Pyrones are naturally occurring unsaturated lactones with promising bioactivities,
such as antimicrobial, cytotoxic, anti-tuberculosis, antioxidant, anti-inflammatory, anti-HIV …
such as antimicrobial, cytotoxic, anti-tuberculosis, antioxidant, anti-inflammatory, anti-HIV …