Technology insight: Plant-derived vesicles—How far from the clinical biotherapeutics and therapeutic drug carriers?

M Cong, S Tan, S Li, L Gao, L Huang, HG Zhang… - Advanced drug delivery …, 2022 - Elsevier
Within the past decades, extracellular vesicles (EVs) have emerged as important mediators
of intercellular communication in both prokaryotes and higher eukaryotes to regulate a …

Plant-derived extracellular vesicles as oral drug delivery carriers

Z Fang, K Liu - Journal of Controlled Release, 2022 - Elsevier
Oral administration is one of the most convenient and widely utilized methods of drug
administration. However, many drugs were difficult to be administered orally due to their …

Plant-derived exosome-like nanovesicles: current progress and prospects

N Mu, J Li, L Zeng, J You, R Li, A Qin, X Liu… - International Journal …, 2023 - Taylor & Francis
Exosomes are small extracellular vesicles, ranging in size from 30–150nm, which can be
derived from various types of cells. In recent years, mammalian-derived exosomes have …

The complex biology of aryl hydrocarbon receptor activation in cancer and beyond

CA Opitz, P Holfelder, MT Prentzell, S Trump - Biochemical Pharmacology, 2023 - Elsevier
The aryl hydrocarbon receptor (AHR) signaling pathway is a complex regulatory network
that plays a critical role in various biological processes, including cellular metabolism …

New insights into the role of dietary triglyceride absorption in obesity and metabolic diseases

X Li, Q Liu, Y Pan, S Chen, Y Zhao, Y Hu - Frontiers in Pharmacology, 2023 - frontiersin.org
The incidence of obesity and associated metabolic diseases is increasing globally,
adversely affecting human health. Dietary fats, especially triglycerides, are an important …

Role of SNAREs in unconventional secretion—Focus on the VAMP7-dependent secretion

S Vats, T Galli - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Intracellular membrane protein trafficking is crucial for both normal cellular physiology and
cell-cell communication. The conventional secretory route follows transport from the …

Emergence of edible plant-derived nanovesicles as functional food components and nanocarriers for therapeutics delivery: potentials in human health and disease

SQ Kim, KH Kim - Cells, 2022 - mdpi.com
Extracellular vesicles (EVs) are a highly heterogeneous population of membranous particles
that are secreted by almost all types of cells across different domains of life, including plants …

Dietary exosome‐like nanoparticles: An updated review on their pharmacological and drug delivery applications

R Anusha, S Priya - Molecular Nutrition & Food Research, 2022 - Wiley Online Library
Exosomes are lipid bilayer membrane‐bound extracellular vesicular structures (30–150 nm)
mainly released by eukaryotic cells of animal origin. Exosome‐like nanoparticles (ELNs) are …

[HTML][HTML] Abnormal tryptophan catabolism in diabetes mellitus and its complications: opportunities and challenges

J Gao, T Yang, B Song, X Ma, Y Ma, X Lin… - Biomedicine & …, 2023 - Elsevier
In recent years, the incidence rate of diabetes mellitus (DM), including type 1 diabetes
mellitus (T1DM), type 2 diabetes mellitus (T2DM), and gestational diabetes mellitus (GDM) …

[HTML][HTML] Plant-derived extracellular vesicles-a novel clinical anti-inflammatory drug carrier worthy of investigation

M Shao, X Jin, S Chen, N Yang, G Feng - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Plant-derived extracellular vesicles (PDEVs) have shown remarkable potential as
sustainable, green, and efficient drug delivery nanocarriers. As natural nanoparticles …