Narcolepsy—clinical spectrum, aetiopathophysiology, diagnosis and treatment

CLA Bassetti, A Adamantidis, D Burdakov… - Nature Reviews …, 2019 - nature.com
Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also
known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is …

Narcolepsy: clinical features, new pathophysiologic insights, and future perspectives

S Overeem, E Mignot, J GertvanDijk… - Journal of Clinical …, 2001 - journals.lww.com
Narcolepsy is characterized by excessive daytime sleepinessand abnormal manifestations
of rapid eye movement sleep such as cataplexy. Theauthors review the clinical features of …

[图书][B] Sleep disorders medicine E-Book: Basic science, technical considerations, and clinical aspects

S Chokroverty - 2009 - books.google.com
Dr. Sudhansu Chokroverty—a world-recognized expert in sleep medicine—presents the
third edition of Sleep Disorders Medicine for the latest developments in this rapidly …

Sleep-related eating disorders: polysomnographic correlates of a heterogeneous syndrome distinct from daytime eating disorders

CH Schenck, TD Hurwitz, SR Bundlie, MW Mahowald - Sleep, 1991 - academic.oup.com
Abstract Over a 5-yr period, 19 adults presented to our sleep disorders center with histories
of involuntary, nocturnal, sleep-related eating that usually occurred with other problematic …

Familial patterns of narcolepsy

C Guilleminault, E Mignot, FC Grumet - The Lancet, 1989 - Elsevier
Familial patterns of narcolepsy were investigated in a clinic population of 334 unrelated
narcoleptic patients. 40% of probands had at least 1 family member with an isolated daytime …

Extensive HLA class II studies in 58 non‐DRB1* 15 (DR2) narcoleptic patients with cataplexy

E Mignot, A Kimura, A Lattermann, X Lin… - Tissue …, 1997 - Wiley Online Library
Narcolepsy is a sleep disorder that has been shown to be tightly associated with HLA DR15
(DR2). In this study, 58 non‐DR15 patients with narco‐lepsy‐cataplexy were typed at the …

Sleep disorders in patients with chronic fatigue

D Buchwald, R Pascualy… - Clinical Infectious …, 1994 - academic.oup.com
This prospective, cohort study examined the prevalence of sleep disorders among highly
selected patients with chronic fatigue. On the basis of responses suggestive of sleep …

Narcolepsy and immunity

E Mignot, M Tafti, WC Dement, FC Grumet - Advances in neuroimmunology, 1995 - Elsevier
Narcolepsy is a neurological disorder known to be associated with human leukocyte antigen
(HLA)-DQB1∗ 0602 in humans. In a canine model, the disorder is also genetically linked to …

Strain differences in sleep and other pathophysiological sequelae of influenza virus infection in naive and immunized mice

LA Toth, JE Rehg, RG Webster - Journal of neuroimmunology, 1995 - Elsevier
To characterize behavioral and physiological alterations induced by viral respiratory
infection, C57BL/6 and BALB/c strains of mice were monitored for 2 days before and 4 days …

HLA antigens in narcolepsy

S Neely, R Rosenberg, JP Spire, J Antel… - Neurology, 1987 - AAN Enterprises
Eighteen black patients with narcolepsy underwent human leukocyte antigen (HLA) typing.
Eleven of the 18 had cataplexy. Twelve patients (66.6%) had HLA-DR2; 7 patients with …