Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

J Xie, Z Shen, Y Anraku, K Kataoka, X Chen - Biomaterials, 2019 - Elsevier
Increasing attention has been paid to the diseases of central nervous system (CNS). The
penetration efficiency of most CNS drugs into the brain parenchyma is rather limited due to …

Design challenges in polymeric scaffolds for tissue engineering

MI Echeverria Molina, KG Malollari… - … in Bioengineering and …, 2021 - frontiersin.org
Numerous surgical procedures are daily performed worldwide to replace and repair
damaged tissue. Tissue engineering is the field devoted to the regeneration of damaged …

Recent progress on polysaccharide-based hydrogels for controlled delivery of therapeutic biomolecules

MI Rial-Hermida, A Rey-Rico… - ACS Biomaterials …, 2021 - ACS Publications
A plethora of applications using polysaccharides have been developed in recent years due
to their availability as well as their frequent nontoxicity and biodegradability. These polymers …

Nanomaterial based drug delivery systems for the treatment of neurodegenerative diseases

SM Asil, J Ahlawat, GG Barroso, M Narayan - Biomaterials science, 2020 - pubs.rsc.org
With an aging population that has been increasing in recent years, the need for the
development of therapeutic approaches for treatment of neurodegenerative disorders (ND) …

Nanoparticles-mediated emerging approaches for effective treatment of ischemic stroke

W He, Z Zhang, X Sha - Biomaterials, 2021 - Elsevier
Ischemic stroke leads to high disability and mortality. The limited delivery efficiency of most
therapeutic substances is a major challenge for effective treatment of ischemic stroke …

Advancements in the use of hydrogels for regenerative medicine: properties and biomedical applications

A Revete, A Aparicio, BA Cisterna… - International Journal …, 2022 - Wiley Online Library
Due to their particular water absorption capacity, hydrogels are the most widely used
scaffolds in biomedical studies to regenerate damaged tissue. Hydrogels can be used in …

Hyaluronic acid biomaterials for central nervous system regenerative medicine

G Jensen, JL Holloway, SE Stabenfeldt - Cells, 2020 - mdpi.com
Hyaluronic acid (HA) is a primary component of the brain extracellular matrix and functions
through cellular receptors to regulate cell behavior within the central nervous system (CNS) …

Extracellular matrix‐mimetic hydrogels for treating neural tissue injury: a focus on fibrin, hyaluronic acid, and elastin‐like polypeptide hydrogels

DW Nelson, RJ Gilbert - Advanced healthcare materials, 2021 - Wiley Online Library
Neurological and functional recovery is limited following central nervous system injury and
severe injury to the peripheral nervous system. Extracellular matrix (ECM)‐mimetic …

Biomimetic hydrogels with spatial-and temporal-controlled chemical cues for tissue engineering

W He, M Reaume, M Hennenfent, BP Lee… - Biomaterials …, 2020 - pubs.rsc.org
Biomimetic hydrogels have emerged as the most useful tissue engineering scaffold
materials. Their versatile chemistry can recapitulate multiple physical and chemical features …

3D printed hydrogels with aligned microchannels to guide neural stem cell migration

C Li, M Kuss, Y Kong, F Nie, X Liu, B Liu… - ACS Biomaterials …, 2021 - ACS Publications
Following traumatic or ischemic brain injury, rapid cell death and extracellular matrix
degradation lead to the formation of a cavity at the brain lesion site, which is responsible for …