We detail a six-stage planar differentiation methodology for generating human pluripotent
stem cell–derived pancreatic β cells (SC-β cells) that secrete high amounts of insulin in …

Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

An open-label, first-in-human phase 1/2 study is being conducted to evaluate the safety and
efficacy of pancreatic endoderm cells (PECs) implanted in non-immunoprotective …

Recent advances in human pluripotent stem cell (hPSC) differentiation protocols have
generated insulin-producing cells resembling pancreatic β cells. While these stem cell …

Human pluripotent stem cells differentiated to insulin-secreting β cells (SC-β cells) in islet
organoids could provide an unlimited cell source for diabetes cell replacement therapy …

Pancreatic islet cells derived from human pluripotent stem cells hold great promise for
modeling and treating diabetes. Differences between stem-cell-derived and primary islets …

For the past century, insulin injections have saved millions of lives, but glycemic instability is
still a persistent challenge for people with diabetes, leading to tremendous morbidity and …

Diabetes mellitus is a pandemic metabolic disorder that results from either the autoimmune
destruction or the dysfunction of insulin-producing pancreatic beta cells. A promising cure is …

Incredible strides have been made since the discovery of insulin almost 100 years ago.
Insulin formulations have improved dramatically, glucose levels can be measured …

Insulin-producing stem cell-derived islets (SC-islets) provide a virtually unlimited cell source
for diabetes cell replacement therapy. While SC-islets are less functional when first …