The phenomenon of protein aggregation and amyloid formation has become the subject of
rapidly increasing research activities across a wide range of scientific disciplines. Such …

Affibody molecules are small (6.5-kDa) affinity proteins based on a three-helix bundle
domain framework. Since their introduction 20 years ago as an alternative to antibodies for …

Affibody molecules are a class of engineered affinity proteins with proven potential for
therapeutic, diagnostic and biotechnological applications. Affibody molecules are small (6.5 …

Affibody molecules can be used as tools for molecular recognition in diagnostic and
therapeutic applications. There are several preclinical studies reported on diagnostic and …

Alzheimer's disease (AD) is an incurable and fatal progressive neurodegenerative disorder
associated with memory and cognition impairment. AD is one of the top medical care …

The amyloid fibrils of beta-amyloid (Aβ) peptides play important roles in the pathology of
Alzheimer's disease. Comprehensive solid-state NMR (SSNMR) structural studies on …

Amyloid is aggregated protein in the form of insoluble fibrils. Amyloid deposition in human
tissue—amyloidosis—is associated with a number of diseases including all common …

In recent genome-wide association studies, the extracellular chaperone protein, clusterin,
has been identified as a newly-discovered risk factor in Alzheimer's disease. We have …

Amyloid diseases such as Alzheimer, Parkinson, and prion diseases are associated with a
specific form of protein misfolding and aggregation into oligomers and fibrils rich in β-sheet …

Assembly of rigid amyloid fibrils with their characteristic cross-β sheet structure is a
molecular signature of numerous neurodegenerative and non-neuropathic disorders …