The endocannabinoid system (ECS) exerts a modulatory effect of important functions such
as neurotransmission, glial activation, oxidative stress, or protein homeostasis …

Simple Summary Neurodegenerative diseases represent an important cause of morbidity
and mortality worldwide. Existing therapeutic options are limited and focus mostly on …

Huntington's disease (HD) symptoms are driven to a large extent by dysfunction of the basal
ganglia circuitry. HD patients exhibit reduced striatal phoshodiesterase 10 (PDE10) levels …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by
the expansion of a CAG trinucleotide repeat encoding an abnormally long polyglutamine …

Purpose To review the developments of recent decades and the current status of PET
molecular imaging in Huntington's disease (HD). Methods A systematic review of PET …

Positron emission tomography (PET) is a molecular imaging modality that enables in vivo
exploration of metabolic processes and especially the pharmacology of neuroreceptors. G …

Neurodegenerative disorders are debilitating conditions that impair patient quality of life and
that represent heavy social-economic burdens to society. Whereas the root of some of these …

This review systematically examines the evidence for shifts in flux through energy
generating biochemical pathways in Huntington's disease (HD) brains from humans and …

Neurodegenerative diseases of the central nervous system frequently affect the locomotor
system resulting in impaired movement and gait. In this study we performed a whole-body …

Cyclic nucleotide phosphodiesterases (PDEs) control the intracellular concentrations of
cAMP and cGMP in virtually all mammalian cells. Accordingly, the PDE family regulates a …