Abstract The Na+/I− symporter (NIS) is an integral plasma membrane glycoprotein that
mediates active I− transport into the thyroid follicular cells, the first step in thyroid hormone …

The Na+/I− symporter (NIS) is an intrinsic membrane protein that mediates the active
transport of iodide into the thyroid and other tissues, such as salivary glands, gastric …

Thyroid iodide uptake is basic to the clinical applications of radioiodine. Iodide uptake
occurs across the membrane of the thyroid follicular cells through an active transporter …

Extrathyroidal cancers could potentially be targeted with 131I, if the Na+/I− symporter (NIS)
were functional. Using immunohistochemical methods we probed 1278 human samples with …

The thyroid-stimulating hormone/thyrotropin (TSH) is the most relevant hormone in the
control of thyroid gland physiology in adulthood. TSH effects on the thyroid gland are …

The recent cloning of the gene encoding the sodium/iodide symporter (NIS) has enabled
better characterization of the molecular mechanisms underlying iodide transport, thus …

The sodium/iodide symporter (NIS) mediates iodide uptake in the thyroid gland and lactating
breast. NIS mRNA and protein expression are detected in most thyroid cancer specimens …

The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates
the active transport of iodide in the thyroid gland and a number of extrathyroidal tissues, in …

Absorption of dietary iodide, presumably in the small intestine, is the first step in iodide (I−)
utilization. From the bloodstream, I− is actively taken up via the Na+/I− symporter (NIS) in the …

The sodium iodide symporter (NIS) is responsible for thyroidal, salivary, gastric, intestinal
and mammary iodide uptake. It was first cloned from the rat in 1996 and shortly thereafter …