Sangerbox: A comprehensive, interaction‐friendly clinical bioinformatics analysis platform

W Shen, Z Song, X Zhong, M Huang, D Shen, P Gao… - Imeta, 2022 - Wiley Online Library
In recent decades, with the continuous development of high‐throughput sequencing
technology, data volume in medical research has increased, at the same time, almost all …

Database resources of the national genomics data center, China national center for bioinformation in 2022

Nucleic Acids Research, 2022 - academic.oup.com
Abstract The National Genomics Data Center (NGDC), part of the China National Center for
Bioinformation (CNCB), provides a family of database resources to support global research …

Database resources of the national genomics data center, China national center for bioinformation in 2023

Nucleic acids research, 2023 - academic.oup.com
Abstract The National Genomics Data Center (NGDC), part of the China National Center for
Bioinformation (CNCB), provides a family of database resources to support global academic …

Cynomolgus monkey embryo model captures gastrulation and early pregnancy

J Li, Q Zhu, J Cao, Y Liu, Y Lu, Y Sun, Q Li, Y Huang… - Cell Stem Cell, 2023 - cell.com
Human stem cell-derived blastoids display similar morphology and cell lineages to normal
blastocysts. However, the ability to investigate their developmental potential is limited. Here …

The Neo-PLANET phase II trial of neoadjuvant camrelizumab plus concurrent chemoradiotherapy in locally advanced adenocarcinoma of stomach or …

Z Tang, Y Wang, D Liu, X Wang, C Xu, Y Yu… - Nature …, 2022 - nature.com
The synergistic effect of neoadjuvant immunotherapy and chemoradiotherapy in gastric
adenocarcinoma is unclear. This phase II trial (NCT03631615) investigated this neoadjuvant …

EasyAmplicon: An easy‐to‐use, open‐source, reproducible, and community‐based pipeline for amplicon data analysis in microbiome research

YX Liu, L Chen, T Ma, X Li, M Zheng, X Zhou, L Chen… - IMeta, 2023 - Wiley Online Library
It is difficult for beginners to learn and use amplicon analysis software because there are so
many software tools to choose from, and all of them need multiple steps of operation. Herein …

Uncovering the transcriptional regulatory network involved in boosting wheat regeneration and transformation

X Liu, XM Bie, X Lin, M Li, H Wang, X Zhang, Y Yang… - Nature Plants, 2023 - nature.com
Genetic transformation is important for gene functional study and crop improvement.
However, it is less effective in wheat. Here we employed a multi-omic analysis strategy to …

Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling

J Zhong, X He, X Gao, Q Liu, Y Zhao, Y Hong… - Nature …, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is usually characterized with disrupted bile acid
(BA) homeostasis. However, the exact role of certain BA in NAFLD is poorly understood …

Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy

B Tang, L Tang, S Li, S Liu, J He, P Li, S Wang… - Nature …, 2023 - nature.com
Intrahepatic cholestasis of pregnancy (ICP) is a female pregnancy-specific disorder that is
characterized by increased serum bile acid and adverse fetal outcomes. The aetiology and …

Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+ T lymphocytes

Z Shi, P Yu, WJ Lin, S Chen, X Hu, S Chen, J Cheng… - Neuron, 2023 - cell.com
The crosstalk between the nervous and immune systems has gained increasing attention for
its emerging role in neurological diseases. Radiation-induced brain injury (RIBI) remains the …