The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …

Cryptococcus neoformans and Cryptococcus gattii are the two etiologic agents of
cryptococcosis. They belong to the phylum Basidiomycota and can be readily distinguished …

Understanding of the taxonomy and phylogeny of Cryptococcus gattii has been advanced by
modern molecular techniques. C. gattii probably diverged from Cryptococcus neoformans …

Few among the millions of fungal species fulfill four basic conditions necessary to infect
humans: high temperature tolerance, ability to invade the human host, lysis and absorption …

Fungi must meet four criteria to infect humans: growth at human body temperatures,
circumvention or penetration of surface barriers, lysis and absorption of tissue, and …

Calcium is an abundant intracellular ion, and calcium homeostasis plays crucial roles in
several cellular processes. The calcineurin signaling cascade is one of the major pathways …

Increases in the incidence and mortality due to the major invasive fungal infections such as
aspergillosis, candidiasis and cryptococcosis caused by the species of Aspergillus, Candida …

Half a century after the introduction of Amphotericin B the management of cryptococcosis
remains unsatisfactory. The disease, caused primarily by the two fungal species …

Fungal infections are becoming one of the main causes of morbidity and mortality in people
with weakened immune systems. Mycoses are becoming more common, despite greater …

Calcineurin signaling plays diverse roles in fungi in regulating stress responses,
morphogenesis and pathogenesis. Although calcineurin signaling is conserved among …