Abstract Flap endonuclease-1 (FEN1) is a member of the Rad2 structure-specific nuclease
family. FEN1 possesses FEN, 5′-exonuclease and gap-endonuclease activities. The …

Completion of lagging strand DNA synthesis requires processing of up to 50 million Okazaki
fragments per cell cycle in mammalian cells. Even in yeast, the Okazaki fragment maturation …

Hepatitis B virus (HBV) is one of the major etiological pathogens for liver cirrhosis and
hepatocellular carcinoma. Chronic HBV infection is a key factor in these severe liver …

Although the physiologic significance of lysine methylation of histones is well known,
whether lysine methylation plays a role in the regulation of nonhistone proteins has not yet …

DNA2, a helicase/nuclease family member, plays versatile roles in processing DNA
intermediates during DNA replication and repair. Yeast Dna2 (yDna2) is essential in RNA …

Efficient and faithful replication of telomeric DNA is critical for maintaining genome integrity.
The G‐quadruplex (G4) structure arising in the repetitive TTAGGG sequence is thought to …

Lung cancer is one of the leading causes of cancer mortality worldwide. The therapeutic
effect of chemotherapy is limited due to the resistance of cancer cells, which remains a …

Functional deficiency of the FEN1 gene has been suggested to cause genomic instability
and cancer predisposition. We have identified a group of FEN1 mutations in human cancer …

Repair of oxidative DNA damage in mitochondria was thought limited to short-patch base
excision repair (SP-BER) replacing a single nucleotide. However, certain oxidative lesions …

Based on the crystal structure of human DNA ligase I complexed with nicked DNA, computer-
aided drug design was used to identify compounds in a database of 1.5 million commercially …