Moyamoya disease is a rare cause of stroke, radiologically characterised by progressive
stenosis of the terminal portion of the internal carotid arteries and compensatory capillary …

To understand the emergence of human higher cognition, we must understand its biological
substrate—the cerebral cortex, which considers itself the crowning achievement of evolution …

Ubiquitylation is a widespread post-translational protein modification in eukaryotes and
marks bacteria that invade the cytosol as cargo for antibacterial autophagy,–. The identity of …

To elucidate the genetics of coronary artery disease (CAD) in the Japanese population, we
conducted a large-scale genome-wide association study of 168,228 individuals of Japanese …

In this report, we, the Research Committee on Moyamoya Disease (Spontaneous Occlusion
of the circle of Willis), describe in detail the changes in the new “Diagnostic Criteria 2021” for …

Underrepresentation of non-European (EUR) populations hinders growth of global precision
medicine. Resources such as imputation reference panels that match the study population …

Abstract The Tohoku Medical Megabank Organization reports the whole-genome
sequences of 1,070 healthy Japanese individuals and construction of a Japanese …

Excessive levels of saturated fatty acids are toxic to cells, although the basis for this
lipotoxicity remains incompletely understood. Here, we analyzed the transcriptome …

Background Moyamoya disease is an idiopathic vascular disorder of intracranial arteries. Its
susceptibility locus has been mapped to 17q25. 3 in Japanese families, but the susceptibility …

Gorillas are humans' closest living relatives after chimpanzees, and are of comparable
importance for the study of human origins and evolution. Here we present the assembly and …